McPhillie MJ - Search Results

1

N-Cinnamoylanthranilates as human TRPA1 modulators: Structure-activity relationships and channel binding sites.

Chandrabalan A, McPhillie MJ, Morice AH, Boa AN, Sadofsky LR. Chandrabalan A, et al. Among authors: mcphillie mj. Eur J Med Chem. 2019 May 15;170:141-156. doi: 10.1016/j.ejmech.2019.02.074. Epub 2019 Mar 4. Eur J Med Chem. 2019. PMID: 30878828

2

Applications of structure-based design to antibacterial drug discovery.

Cain R, Narramore S, McPhillie M, Simmons K, Fishwick CW. Cain R, et al. Bioorg Chem. 2014 Aug;55:69-76. doi: 10.1016/j.bioorg.2014.05.008. Epub 2014 Jun 2. Bioorg Chem. 2014. PMID: 24962384 Review.

3

New Opportunities in the Structure-based Design of Anti-Protozoan Agents.

Gordon JA, Fishwick CW, McPhillie MJ. Gordon JA, et al. Among authors: mcphillie mj. Curr Top Med Chem. 2017;17(1):79-90. doi: 10.2174/1568026616666160719164542. Curr Top Med Chem. 2017. PMID: 27531028 Free article. Review.

4

The Growing Role of Electron Microscopy in Anti-parasitic Drug Discovery.

Johnson RM, Rawson S, McPhillie MJ, Fishwick CWG, Muench SP. Johnson RM, et al. Among authors: mcphillie mj. Curr Med Chem. 2018;25(39):5279-5290. doi: 10.2174/0929867324666171109120526. Curr Med Chem. 2018. PMID: 29119913 Free article. Review.

5

Discovery of a benzimidazole-based dual FLT3/TrKA inhibitor targeting acute myeloid leukemia.

Dokla EME, Abdel-Aziz AK, Milik SN, McPhillie MJ, Minucci S, Abouzid KAM. Dokla EME, et al. Among authors: mcphillie mj. Bioorg Med Chem. 2022 Feb 15;56:116596. doi: 10.1016/j.bmc.2021.116596. Epub 2021 Dec 30. Bioorg Med Chem. 2022. PMID: 35033885

6

Recent developments in the structural characterisation of the IR and IGF1R: implications for the design of IR-IGF1R hybrid receptor modulators.

Turvey SJ, McPhillie MJ, Kearney MT, Muench SP, Simmons KJ, Fishwick CWG. Turvey SJ, et al. Among authors: mcphillie mj. RSC Med Chem. 2022 Feb 21;13(4):360-374. doi: 10.1039/d1md00300c. eCollection 2022 Apr 20. RSC Med Chem. 2022. PMID: 35647546 Free PMC article. Review.

7

De novo design of type II topoisomerase inhibitors as potential antimicrobial agents targeting a novel binding region.

Orritt KM, Feng L, Newell JF, Sutton JN, Grossman S, Germe T, Abbott LR, Jackson HL, Bury BKL, Maxwell A, McPhillie MJ, Fishwick CWG. Orritt KM, et al. Among authors: mcphillie mj. RSC Med Chem. 2022 Jun 16;13(7):831-839. doi: 10.1039/d2md00049k. eCollection 2022 Jul 20. RSC Med Chem. 2022. PMID: 35919336 Free PMC article.

8

Development of a triclosan scaffold which allows for adaptations on both the A- and B-ring for transport peptides.

Muench SP, Stec J, Zhou Y, Afanador GA, McPhillie MJ, Hickman MR, Lee PJ, Leed SE, Auschwitz JM, Prigge ST, Rice DW, McLeod R. Muench SP, et al. Among authors: mcphillie mj. Bioorg Med Chem Lett. 2013 Jun 15;23(12):3551-5. doi: 10.1016/j.bmcl.2013.04.035. Epub 2013 Apr 24. Bioorg Med Chem Lett. 2013. PMID: 23664871 Free PMC article.

9

An in silico structure-based approach to anti-infective drug discovery.

Cunningham F, McPhillie MJ, Johnson AP, Fishwick CW. Cunningham F, et al. Among authors: mcphillie mj. Parasitology. 2014 Jan;141(1):17-27. doi: 10.1017/S0031182013000693. Epub 2013 Jun 17. Parasitology. 2014. PMID: 23768800 Review.

10

Structure-based ligand design of novel bacterial RNA polymerase inhibitors.

McPhillie MJ, Trowbridge R, Mariner KR, O'Neill AJ, Johnson AP, Chopra I, Fishwick CW. McPhillie MJ, et al. ACS Med Chem Lett. 2011 Jul 29;2(10):729-34. doi: 10.1021/ml200087m. eCollection 2011 Oct 13. ACS Med Chem Lett. 2011. PMID: 24900260 Free PMC article.

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