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Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3.
Farrelly LA, Thompson RE, Zhao S, Lepack AE, Lyu Y, Bhanu NV, Zhang B, Loh YE, Ramakrishnan A, Vadodaria KC, Heard KJ, Erikson G, Nakadai T, Bastle RM, Lukasak BJ, Zebroski H 3rd, Alenina N, Bader M, Berton O, Roeder RG, Molina H, Gage FH, Shen L, Garcia BA, Li H, Muir TW, Maze I. Farrelly LA, et al. Among authors: lyu y. Nature. 2019 Mar;567(7749):535-539. doi: 10.1038/s41586-019-1024-7. Epub 2019 Mar 13. Nature. 2019. PMID: 30867594 Free PMC article.
Dopaminylation of histone H3 in ventral tegmental area regulates cocaine seeking.
Lepack AE, Werner CT, Stewart AF, Fulton SL, Zhong P, Farrelly LA, Smith ACW, Ramakrishnan A, Lyu Y, Bastle RM, Martin JA, Mitra S, O'Connor RM, Wang ZJ, Molina H, Turecki G, Shen L, Yan Z, Calipari ES, Dietz DM, Kenny PJ, Maze I. Lepack AE, et al. Among authors: lyu y. Science. 2020 Apr 10;368(6487):197-201. doi: 10.1126/science.aaw8806. Science. 2020. PMID: 32273471 Free PMC article.
Rescue of deficits by Brwd1 copy number restoration in the Ts65Dn mouse model of Down syndrome.
Fulton SL, Wenderski W, Lepack AE, Eagle AL, Fanutza T, Bastle RM, Ramakrishnan A, Hays EC, Neal A, Bendl J, Farrelly LA, Al-Kachak A, Lyu Y, Cetin B, Chan JC, Tran TN, Neve RL, Roper RJ, Brennand KJ, Roussos P, Schimenti JC, Friedman AK, Shen L, Blitzer RD, Robison AJ, Crabtree GR, Maze I. Fulton SL, et al. Among authors: lyu y. Nat Commun. 2022 Oct 26;13(1):6384. doi: 10.1038/s41467-022-34200-0. Nat Commun. 2022. PMID: 36289231 Free PMC article.
Flexible and site-specific manipulation of histones in live animals.
Finkin-Groner E, Al-Kachak A, Agustinus A, Bastle R, Lepack A, Lyu Y, Maze I, David Y. Finkin-Groner E, et al. Among authors: lyu y. bioRxiv [Preprint]. 2023 Mar 20:2023.03.19.533378. doi: 10.1101/2023.03.19.533378. bioRxiv. 2023. PMID: 36993231 Free PMC article. Preprint.
Histone H3 serotonylation dynamics in dorsal raphe nucleus contribute to stress- and antidepressant-mediated gene expression and behavior.
Al-Kachak A, Fulton SL, Di Salvo G, Chan JC, Farrelly LA, Lepack AE, Bastle RM, Kong L, Cathomas F, Newman EL, Menard C, Ramakrishnan A, Safovich P, Lyu Y, Covington HE 3rd, Shen L, Gleason K, Tamminga CA, Russo SJ, Maze I. Al-Kachak A, et al. Among authors: lyu y. bioRxiv [Preprint]. 2023 Sep 16:2023.05.04.539464. doi: 10.1101/2023.05.04.539464. bioRxiv. 2023. Update in: Nat Commun. 2024 Jun 13;15(1):5042. doi: 10.1038/s41467-024-49336-4 PMID: 37205414 Free PMC article. Updated. Preprint.
Histone serotonylation in dorsal raphe nucleus contributes to stress- and antidepressant-mediated gene expression and behavior.
Al-Kachak A, Di Salvo G, Fulton SL, Chan JC, Farrelly LA, Lepack AE, Bastle RM, Kong L, Cathomas F, Newman EL, Menard C, Ramakrishnan A, Safovich P, Lyu Y, Covington HE 3rd, Shen L, Gleason K, Tamminga CA, Russo SJ, Maze I. Al-Kachak A, et al. Among authors: lyu y. Nat Commun. 2024 Jun 13;15(1):5042. doi: 10.1038/s41467-024-49336-4. Nat Commun. 2024. PMID: 38871707 Free PMC article.
2,207 results