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A self-defeating anabolic program leads to β-cell apoptosis in endoplasmic reticulum stress-induced diabetes via regulation of amino acid flux.
Krokowski D, Han J, Saikia M, Majumder M, Yuan CL, Guan BJ, Bevilacqua E, Bussolati O, Bröer S, Arvan P, Tchórzewski M, Snider MD, Puchowicz M, Croniger CM, Kimball SR, Pan T, Koromilas AE, Kaufman RJ, Hatzoglou M. Krokowski D, et al. Among authors: arvan p. J Biol Chem. 2013 Jun 14;288(24):17202-13. doi: 10.1074/jbc.M113.466920. Epub 2013 May 3. J Biol Chem. 2013. PMID: 23645676 Free PMC article.
Biological behaviors of mutant proinsulin contribute to the phenotypic spectrum of diabetes associated with insulin gene mutations.
Wang H, Saint-Martin C, Xu J, Ding L, Wang R, Feng W, Liu M, Shu H, Fan Z, Haataja L, Arvan P, Bellanné-Chantelot C, Cui J, Huang Y. Wang H, et al. Among authors: arvan p. Mol Cell Endocrinol. 2020 Dec 1;518:111025. doi: 10.1016/j.mce.2020.111025. Epub 2020 Sep 8. Mol Cell Endocrinol. 2020. PMID: 32916194 Free PMC article.
Adaptation to chronic ER stress enforces pancreatic β-cell plasticity.
Chen CW, Guan BJ, Alzahrani MR, Gao Z, Gao L, Bracey S, Wu J, Mbow CA, Jobava R, Haataja L, Zalavadia AH, Schaffer AE, Lee H, LaFramboise T, Bederman I, Arvan P, Mathews CE, Gerling IC, Kaestner KH, Tirosh B, Engin F, Hatzoglou M. Chen CW, et al. Among authors: arvan p. Nat Commun. 2022 Aug 8;13(1):4621. doi: 10.1038/s41467-022-32425-7. Nat Commun. 2022. PMID: 35941159 Free PMC article.
IER3IP1 is critical for maintaining glucose homeostasis through regulating the endoplasmic reticulum function and survival of β cells.
Yang J, Zhen J, Feng W, Fan Z, Ding L, Yang X, Huang Y, Shu H, Xie J, Li X, Qiao J, Fan Y, Sun J, Li N, Liu T, Wang S, Zhang X, Arvan P, Liu M. Yang J, et al. Among authors: arvan p. Proc Natl Acad Sci U S A. 2022 Nov 8;119(45):e2204443119. doi: 10.1073/pnas.2204443119. Epub 2022 Nov 2. Proc Natl Acad Sci U S A. 2022. PMID: 36322741 Free PMC article.
216 results