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Methyl sulfonamide substituents improve the pharmacokinetic properties of bicyclic 2-pyridone based Chlamydia trachomatis inhibitors.
Kulén M, Núñez-Otero C, Cairns AG, Silver J, Lindgren AEG, Wede E, Singh P, Vielfort K, Bahnan W, Good JAD, Svensson R, Bergström S, Gylfe Å, Almqvist F. Kulén M, et al. Among authors: singh p. Medchemcomm. 2019 Oct 17;10(11):1966-1987. doi: 10.1039/c9md00405j. eCollection 2019 Nov 1. Medchemcomm. 2019. PMID: 32206238 Free PMC article.
Intramolecular Povarov Reactions for the Synthesis of Chromenopyridine Fused 2-Pyridone Polyheterocycles Binding to α-Synuclein and Amyloid-β Fibrils.
Adolfsson DE, Tyagi M, Singh P, Deuschmann A, Ådén J, Gharibyan AL, Jayaweera SW, Lindgren AEG, Olofsson A, Almqvist F. Adolfsson DE, et al. Among authors: singh p. J Org Chem. 2020 Nov 6;85(21):14174-14189. doi: 10.1021/acs.joc.0c01699. Epub 2020 Oct 25. J Org Chem. 2020. PMID: 33099999 Free PMC article.
Selected applications of Meldrum's acid - a tutorial.
Brosge F, Singh P, Almqvist F, Bolm C. Brosge F, et al. Among authors: singh p. Org Biomol Chem. 2021 Jun 16;19(23):5014-5027. doi: 10.1039/d1ob00395j. Org Biomol Chem. 2021. PMID: 34019615 Review.
Ring-fused 2-pyridones effective against multidrug-resistant Gram-positive pathogens and synergistic with standard-of-care antibiotics.
Nye TM, Tükenmez H, Singh P, Flores-Mireles AL, Obernuefemann CLP, Pinkner JS, Sarkar S, Bonde M, Lindgren AEG, Dodson KW, Johansson J, Almqvist F, Caparon MG, Hultgren SJ. Nye TM, et al. Among authors: singh p. Proc Natl Acad Sci U S A. 2022 Oct 25;119(43):e2210912119. doi: 10.1073/pnas.2210912119. Epub 2022 Oct 17. Proc Natl Acad Sci U S A. 2022. PMID: 36252016 Free PMC article.
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