Olofsson A - Search Results

1

Pyridine-Fused 2-Pyridones via Povarov and A³ Reactions: Rapid Generation of Highly Functionalized Tricyclic Heterocycles Capable of Amyloid Fibril Binding.

Singh P, Adolfsson DE, Ådén J, Cairns AG, Bartens C, Brännström K, Olofsson A, Almqvist F. Singh P, et al. Among authors: olofsson a. J Org Chem. 2019 Apr 5;84(7):3887-3903. doi: 10.1021/acs.joc.8b03015. Epub 2019 Mar 20. J Org Chem. 2019. PMID: 30862161

2

Intramolecular Povarov Reactions for the Synthesis of Chromenopyridine Fused 2-Pyridone Polyheterocycles Binding to α-Synuclein and Amyloid-β Fibrils.

Adolfsson DE, Tyagi M, Singh P, Deuschmann A, Ådén J, Gharibyan AL, Jayaweera SW, Lindgren AEG, Olofsson A, Almqvist F. Adolfsson DE, et al. Among authors: olofsson a. J Org Chem. 2020 Nov 6;85(21):14174-14189. doi: 10.1021/acs.joc.0c01699. Epub 2020 Oct 25. J Org Chem. 2020. PMID: 33099999 Free PMC article.

3

Tandem Ring Opening/Intramolecular [2 + 2] Cycloaddition Reaction for the Synthesis of Cyclobutane Fused Thiazolino-2-Pyridones.

Tyagi M, Adolfsson DE, Singh P, Ådén J, Jayaweera SW, Gharibyan A, Bharate JB, Kiss A, Sarkar S, Olofsson A, Almqvist F. Tyagi M, et al. Among authors: olofsson a. J Org Chem. 2021 Dec 3;86(23):16582-16592. doi: 10.1021/acs.joc.1c01875. Epub 2021 Nov 12. J Org Chem. 2021. PMID: 34767366 Free PMC article.

4

K₂S₂O₈-mediated coupling of 6-amino-7-aminomethyl-thiazolino-pyridones with aldehydes to construct amyloid affecting pyrimidine-fused thiazolino-2-pyridones.

Bharate JB, Ådén J, Gharibyan A, Adolfsson DE, Jayaweera SW, Singh P, Vielfort K, Tyagi M, Bonde M, Bergström S, Olofsson A, Almqvist F. Bharate JB, et al. Among authors: olofsson a. Org Biomol Chem. 2021 Nov 18;19(44):9758-9772. doi: 10.1039/d1ob01580j. Org Biomol Chem. 2021. PMID: 34730163

5

Microwave-assisted decarboxylation of bicyclic 2-pyridone scaffolds and identification of Abeta-peptide aggregation inhibitors.

Aberg V, Norman F, Chorell E, Westermark A, Olofsson A, Sauer-Eriksson AE, Almqvist F. Aberg V, et al. Among authors: olofsson a. Org Biomol Chem. 2005 Aug 7;3(15):2817-23. doi: 10.1039/b503294f. Epub 2005 Jun 29. Org Biomol Chem. 2005. PMID: 16032359

6

Modulation of α-synuclein fibrillization by ring-fused 2-pyridones: templation and inhibition involve oligomers with different structure.

Horvath I, Sellstedt M, Weise C, Nordvall LM, Krishna Prasad G, Olofsson A, Larsson G, Almqvist F, Wittung-Stafshede P. Horvath I, et al. Among authors: olofsson a. Arch Biochem Biophys. 2013 Apr 15;532(2):84-90. doi: 10.1016/j.abb.2013.01.012. Epub 2013 Feb 9. Arch Biochem Biophys. 2013. PMID: 23399432

7

Clicked tacrine conjugates as acetylcholinesterase and β-amyloid directed compounds.

Ouberai M, Brannstrom K, Vestling M, Olofsson A, Dumy P, Chierici S, Garcia J. Ouberai M, et al. Among authors: olofsson a. Org Biomol Chem. 2011 Feb 21;9(4):1140-7. doi: 10.1039/c0ob00393j. Epub 2010 Dec 10. Org Biomol Chem. 2011. PMID: 21152577

8

Structural topology and activation of an initial adenylate kinase-substrate complex.

Ådén J, Weise CF, Brännström K, Olofsson A, Wolf-Watz M. Ådén J, et al. Among authors: olofsson a. Biochemistry. 2013 Feb 12;52(6):1055-61. doi: 10.1021/bi301460k. Epub 2013 Feb 1. Biochemistry. 2013. PMID: 23339454

9

The N-terminal region of amyloid β controls the aggregation rate and fibril stability at low pH through a gain of function mechanism.

Brännström K, Öhman A, Nilsson L, Pihl M, Sandblad L, Olofsson A. Brännström K, et al. Among authors: olofsson a. J Am Chem Soc. 2014 Aug 6;136(31):10956-64. doi: 10.1021/ja503535m. Epub 2014 Jul 28. J Am Chem Soc. 2014. PMID: 25014209

10

The role of histidines in amyloid β fibril assembly.

Brännström K, Islam T, Sandblad L, Olofsson A. Brännström K, et al. Among authors: olofsson a. FEBS Lett. 2017 Apr;591(8):1167-1175. doi: 10.1002/1873-3468.12616. Epub 2017 Apr 3. FEBS Lett. 2017. PMID: 28267202 Free PMC article.

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