Guo B - Search Results

1

Optimization of P2Y₁₂ Antagonist Ethyl 6-(4-((Benzylsulfonyl)carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate (AZD1283) Led to the Discovery of an Oral Antiplatelet Agent with Improved Druglike Properties.

Kong D, Xue T, Guo B, Cheng J, Liu S, Wei J, Lu Z, Liu H, Gong G, Lan T, Hu W, Yang Y. Kong D, et al. Among authors: guo b. J Med Chem. 2019 Mar 28;62(6):3088-3106. doi: 10.1021/acs.jmedchem.8b01971. Epub 2019 Mar 19. J Med Chem. 2019. PMID: 30843696

2

Design, synthesis, and structure-activity relationship studies of highly potent novel benzoxazinyl-oxazolidinone antibacterial agents.

Xin Q, Fan H, Guo B, He H, Gao S, Wang H, Huang Y, Yang Y. Xin Q, et al. Among authors: guo b. J Med Chem. 2011 Nov 10;54(21):7493-502. doi: 10.1021/jm200614t. Epub 2011 Oct 12. J Med Chem. 2011. PMID: 21955296

3

Solubility-driven optimization of (pyridin-3-yl) benzoxazinyl-oxazolidinones leading to a promising antibacterial agent.

Guo B, Fan H, Xin Q, Chu W, Wang H, Huang Y, Chen X, Yang Y. Guo B, et al. J Med Chem. 2013 Mar 28;56(6):2642-50. doi: 10.1021/jm4000598. Epub 2013 Mar 13. J Med Chem. 2013. PMID: 23428155

4

Synthesis and biological evaluation of novel benzoxazinyl-oxazolidinones as potential antibacterial agents.

Guo B, Fan H, Xin Q, Chu W, Wang H, Yang Y. Guo B, et al. Bioorg Med Chem Lett. 2013 Jul 1;23(13):3697-9. doi: 10.1016/j.bmcl.2013.05.023. Epub 2013 May 17. Bioorg Med Chem Lett. 2013. PMID: 23721807

5

Design, synthesis, and structure-activity and structure-pharmacokinetic relationship studies of novel [6,6,5] tricyclic fused oxazolidinones leading to the discovery of a potent, selective, and orally bioavailable FXa inhibitor.

Xue T, Ding S, Guo B, Zhou Y, Sun P, Wang H, Chu W, Gong G, Wang Y, Chen X, Yang Y. Xue T, et al. Among authors: guo b. J Med Chem. 2014 Sep 25;57(18):7770-91. doi: 10.1021/jm501045e. Epub 2014 Sep 15. J Med Chem. 2014. PMID: 25179681

6

Synthesis and structure-activity relationship studies of novel [6,6,5] tricyclic oxazolidinone derivatives as potential antibacterial agents.

Xue T, Ding S, Guo B, Chu W, Wang H, Yang Y. Xue T, et al. Among authors: guo b. Bioorg Med Chem Lett. 2015;25(10):2203-10. doi: 10.1016/j.bmcl.2015.03.053. Epub 2015 Mar 25. Bioorg Med Chem Lett. 2015. PMID: 25838143

7

Design and optimization of 2,3-dihydrobenzo[b][1,4]dioxine propanoic acids as novel GPR40 agonists with improved pharmacokinetic and safety profiles.

Guo B, Guo S, Huang J, Li J, Li J, Chen Q, Zhou X, Xie X, Yang Y. Guo B, et al. Among authors: guo s. Bioorg Med Chem. 2018 Dec 1;26(22):5780-5791. doi: 10.1016/j.bmc.2018.10.019. Epub 2018 Oct 22. Bioorg Med Chem. 2018. PMID: 30392954

8

Synthesis and biological evaluation of novel potent FFA1 agonists containing 2,3-dihydrobenzo[b][1,4]dioxine.

Kong D, Guo S, Yang Y, Guo B, Xie X, Hu W. Kong D, et al. Among authors: guo b, guo s. Bioorg Med Chem Lett. 2019 Mar 15;29(6):848-852. doi: 10.1016/j.bmcl.2019.01.014. Epub 2019 Jan 17. Bioorg Med Chem Lett. 2019. PMID: 30685095

9

Design, Synthesis, and Biological Evaluation of Novel DNA Gyrase-Inhibiting Spiropyrimidinetriones as Potent Antibiotics for Treatment of Infections Caused by Multidrug-Resistant Gram-Positive Bacteria.

Shi C, Zhang Y, Wang T, Lu W, Zhang S, Guo B, Chen Q, Luo C, Zhou X, Yang Y. Shi C, et al. Among authors: guo b. J Med Chem. 2019 Mar 28;62(6):2950-2973. doi: 10.1021/acs.jmedchem.8b01750. Epub 2019 Mar 6. J Med Chem. 2019. PMID: 30698430

10

Design, Synthesis, and Biological Evaluation of Novel Pyrimido[4,5-b]indole Derivatives Against Gram-Negative Multidrug-Resistant Pathogens.

Kong Q, Pan W, Xu H, Xue Y, Guo B, Meng X, Luo C, Wang T, Zhang S, Yang Y. Kong Q, et al. Among authors: guo b. J Med Chem. 2021 Jun 24;64(12):8644-8665. doi: 10.1021/acs.jmedchem.1c00621. Epub 2021 Jun 3. J Med Chem. 2021. PMID: 34080858

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