Cheng J - Search Results

1

Optimization of P2Y₁₂ Antagonist Ethyl 6-(4-((Benzylsulfonyl)carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate (AZD1283) Led to the Discovery of an Oral Antiplatelet Agent with Improved Druglike Properties.

Kong D, Xue T, Guo B, Cheng J, Liu S, Wei J, Lu Z, Liu H, Gong G, Lan T, Hu W, Yang Y. Kong D, et al. Among authors: cheng j. J Med Chem. 2019 Mar 28;62(6):3088-3106. doi: 10.1021/acs.jmedchem.8b01971. Epub 2019 Mar 19. J Med Chem. 2019. PMID: 30843696

2

Evaluation of the antipsychotic effect of bi-acetylated l-stepholidine (l-SPD-A), a novel dopamine and serotonin receptor dual ligand.

Guo Y, Zhang H, Chen X, Cai W, Cheng J, Yang Y, Jin G, Zhen X. Guo Y, et al. Among authors: cheng j. Schizophr Res. 2009 Nov;115(1):41-9. doi: 10.1016/j.schres.2009.08.002. Epub 2009 Sep 9. Schizophr Res. 2009. PMID: 19744833

3

Enantioselective total synthesis of (-)-(S)-stepholidine.

Cheng JJ, Yang YS. Cheng JJ, et al. J Org Chem. 2009 Dec 4;74(23):9225-8. doi: 10.1021/jo9020826. J Org Chem. 2009. PMID: 19950885

4

Design, synthesis, and structure-activity relationship studies of conformationally restricted mutilin 14-carbamates.

Fu L, Liu X, Ling C, Cheng J, Guo X, He H, Ding S, Yang Y. Fu L, et al. Among authors: cheng j. Bioorg Med Chem Lett. 2012 Jan 15;22(2):814-9. doi: 10.1016/j.bmcl.2011.12.063. Epub 2011 Dec 20. Bioorg Med Chem Lett. 2012. PMID: 22209487

5

Optimization of 2-phenylcyclopropylmethylamines as selective serotonin 2C receptor agonists and their evaluation as potential antipsychotic agents.

Cheng J, Giguère PM, Onajole OK, Lv W, Gaisin A, Gunosewoyo H, Schmerberg CM, Pogorelov VM, Rodriguiz RM, Vistoli G, Wetsel WC, Roth BL, Kozikowski AP. Cheng J, et al. J Med Chem. 2015 Feb 26;58(4):1992-2002. doi: 10.1021/jm5019274. Epub 2015 Feb 10. J Med Chem. 2015. PMID: 25633969 Free PMC article.

6

Further Advances in Optimizing (2-Phenylcyclopropyl)methylamines as Novel Serotonin 2C Agonists: Effects on Hyperlocomotion, Prepulse Inhibition, and Cognition Models.

Cheng J, Giguere PM, Schmerberg CM, Pogorelov VM, Rodriguiz RM, Huang XP, Zhu H, McCorvy JD, Wetsel WC, Roth BL, Kozikowski AP. Cheng J, et al. J Med Chem. 2016 Jan 28;59(2):578-91. doi: 10.1021/acs.jmedchem.5b01153. Epub 2016 Jan 13. J Med Chem. 2016. PMID: 26704965 Free PMC article.

7

Design and Discovery of Functionally Selective Serotonin 2C (5-HT_2C) Receptor Agonists.

Cheng J, McCorvy JD, Giguere PM, Zhu H, Kenakin T, Roth BL, Kozikowski AP. Cheng J, et al. J Med Chem. 2016 Nov 10;59(21):9866-9880. doi: 10.1021/acs.jmedchem.6b01194. Epub 2016 Oct 25. J Med Chem. 2016. PMID: 27726356

8

Discovery of N-Substituted (2-Phenylcyclopropyl)methylamines as Functionally Selective Serotonin 2C Receptor Agonists for Potential Use as Antipsychotic Medications.

Zhang G, Cheng J, McCorvy JD, Lorello PJ, Caldarone BJ, Roth BL, Kozikowski AP. Zhang G, et al. Among authors: cheng j. J Med Chem. 2017 Jul 27;60(14):6273-6288. doi: 10.1021/acs.jmedchem.7b00584. Epub 2017 Jul 18. J Med Chem. 2017. PMID: 28657744 Free PMC article.

9

Biased Ligands of G Protein-Coupled Receptors (GPCRs): Structure-Functional Selectivity Relationships (SFSRs) and Therapeutic Potential.

Tan L, Yan W, McCorvy JD, Cheng J. Tan L, et al. Among authors: cheng j. J Med Chem. 2018 Nov 21;61(22):9841-9878. doi: 10.1021/acs.jmedchem.8b00435. Epub 2018 Jul 10. J Med Chem. 2018. PMID: 29939744 Review.

10

Design of fluorinated cyclopropane derivatives of 2-phenylcyclopropylmethylamine leading to identification of a selective serotonin 2C (5-HT_2C) receptor agonist without 5-HT_2B agonism.

Zhang G, McCorvy JD, Shen S, Cheng J, Roth BL, Kozikowski AP. Zhang G, et al. Among authors: cheng j. Eur J Med Chem. 2019 Nov 15;182:111626. doi: 10.1016/j.ejmech.2019.111626. Epub 2019 Aug 14. Eur J Med Chem. 2019. PMID: 31445232 Free PMC article.

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