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Page 1
Genetic and environmental perturbations lead to regulatory decoherence.
Lea A, Subramaniam M, Ko A, Lehtimäki T, Raitoharju E, Kähönen M, Seppälä I, Mononen N, Raitakari OT, Ala-Korpela M, Pajukanta P, Zaitlen N, Ayroles JF. Lea A, et al. Among authors: seppala i. Elife. 2019 Mar 5;8:e40538. doi: 10.7554/eLife.40538. Elife. 2019. PMID: 30834892 Free PMC article.
Integrative approaches for large-scale transcriptome-wide association studies.
Gusev A, Ko A, Shi H, Bhatia G, Chung W, Penninx BW, Jansen R, de Geus EJ, Boomsma DI, Wright FA, Sullivan PF, Nikkola E, Alvarez M, Civelek M, Lusis AJ, Lehtimäki T, Raitoharju E, Kähönen M, Seppälä I, Raitakari OT, Kuusisto J, Laakso M, Price AL, Pajukanta P, Pasaniuc B. Gusev A, et al. Among authors: seppala i. Nat Genet. 2016 Mar;48(3):245-52. doi: 10.1038/ng.3506. Epub 2016 Feb 8. Nat Genet. 2016. PMID: 26854917 Free PMC article.
Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses.
Aho V, Ollila HM, Kronholm E, Bondia-Pons I, Soininen P, Kangas AJ, Hilvo M, Seppälä I, Kettunen J, Oikonen M, Raitoharju E, Hyötyläinen T, Kähönen M, Viikari JS, Härmä M, Sallinen M, Olkkonen VM, Alenius H, Jauhiainen M, Paunio T, Lehtimäki T, Salomaa V, Orešič M, Raitakari OT, Ala-Korpela M, Porkka-Heiskanen T. Aho V, et al. Among authors: seppala i. Sci Rep. 2016 Apr 22;6:24828. doi: 10.1038/srep24828. Sci Rep. 2016. PMID: 27102866 Free PMC article.
Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors.
Ahola-Olli AV, Würtz P, Havulinna AS, Aalto K, Pitkänen N, Lehtimäki T, Kähönen M, Lyytikäinen LP, Raitoharju E, Seppälä I, Sarin AP, Ripatti S, Palotie A, Perola M, Viikari JS, Jalkanen S, Maksimow M, Salomaa V, Salmi M, Kettunen J, Raitakari OT. Ahola-Olli AV, et al. Among authors: seppala i. Am J Hum Genet. 2017 Jan 5;100(1):40-50. doi: 10.1016/j.ajhg.2016.11.007. Epub 2016 Dec 15. Am J Hum Genet. 2017. PMID: 27989323 Free PMC article.
Multivariate Genome-wide Association Analysis of a Cytokine Network Reveals Variants with Widespread Immune, Haematological, and Cardiometabolic Pleiotropy.
Nath AP, Ritchie SC, Grinberg NF, Tang HH, Huang QQ, Teo SM, Ahola-Olli AV, Würtz P, Havulinna AS, Santalahti K, Pitkänen N, Lehtimäki T, Kähönen M, Lyytikäinen LP, Raitoharju E, Seppälä I, Sarin AP, Ripatti S, Palotie A, Perola M, Viikari JS, Jalkanen S, Maksimow M, Salmi M, Wallace C, Raitakari OT, Salomaa V, Abraham G, Kettunen J, Inouye M. Nath AP, et al. Among authors: seppala i. Am J Hum Genet. 2019 Dec 5;105(6):1076-1090. doi: 10.1016/j.ajhg.2019.10.001. Epub 2019 Oct 31. Am J Hum Genet. 2019. PMID: 31679650 Free PMC article.
Adulthood blood levels of hsa-miR-29b-3p associate with preterm birth and adult metabolic and cognitive health.
Marttila S, Rovio S, Mishra PP, Seppälä I, Lyytikäinen LP, Juonala M, Waldenberger M, Oksala N, Ala-Korpela M, Harville E, Hutri-Kähönen N, Kähönen M, Raitakari O, Lehtimäki T, Raitoharju E. Marttila S, et al. Among authors: seppala i. Sci Rep. 2021 Apr 28;11(1):9203. doi: 10.1038/s41598-021-88465-4. Sci Rep. 2021. PMID: 33911114 Free PMC article.
Mitochondrial genome-wide analysis of nuclear DNA methylation quantitative trait loci.
Laaksonen J, Mishra PP, Seppälä I, Raitoharju E, Marttila S, Mononen N, Lyytikäinen LP, Kleber ME, Delgado GE, Lepistö M, Almusa H, Ellonen P, Lorkowski S, März W, Hutri-Kähönen N, Raitakari O, Kähönen M, Salonen JT, Lehtimäki T. Laaksonen J, et al. Among authors: seppala i. Hum Mol Genet. 2022 May 19;31(10):1720-1732. doi: 10.1093/hmg/ddab339. Hum Mol Genet. 2022. PMID: 35077545 Free PMC article.
Discovery of mitochondrial DNA variants associated with genome-wide blood cell gene expression: a population-based mtDNA sequencing study.
Laaksonen J, Seppälä I, Raitoharju E, Mononen N, Lyytikäinen LP, Waldenberger M, Illig T, Lepistö M, Almusa H, Ellonen P, Hutri-Kähönen N, Juonala M, Kähönen M, Raitakari O, Salonen JT, Lehtimäki T. Laaksonen J, et al. Among authors: seppala i. Hum Mol Genet. 2019 Apr 15;28(8):1381-1391. doi: 10.1093/hmg/ddz011. Hum Mol Genet. 2019. PMID: 30629177 Free article.
Childhood physical, environmental, and genetic predictors of adult hypertension: the cardiovascular risk in young Finns study.
Juhola J, Oikonen M, Magnussen CG, Mikkilä V, Siitonen N, Jokinen E, Laitinen T, Würtz P, Gidding SS, Taittonen L, Seppälä I, Jula A, Kähönen M, Hutri-Kähönen N, Lehtimäki T, Viikari JS, Juonala M, Raitakari OT. Juhola J, et al. Among authors: seppala i. Circulation. 2012 Jul 24;126(4):402-9. doi: 10.1161/CIRCULATIONAHA.111.085977. Epub 2012 Jun 20. Circulation. 2012. PMID: 22718800
240 results