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Page 1
Small-molecule inhibition of SARS-CoV-2 NSP14 RNA cap methyltransferase.
Meyer C, Garzia A, Miller MW, Huggins DJ, Myers RW, Hoffmann HH, Ashbrook AW, Jannath SY, Liverton N, Kargman S, Zimmerman M, Nelson AM, Sharma V, Dolgov E, Cangialosi J, Penalva-Lopez S, Alvarez N, Chang CW, Oswal N, Gonzalez I, Rasheed R, Goldgirsh K, Davis JA, Ramos-Espiritu L, Menezes MR, Larson C, Nitsche J, Ganichkin O, Alwaseem H, Molina H, Steinbacher S, Glickman JF, Perlin DS, Rice CM, Meinke PT, Tuschl T. Meyer C, et al. Among authors: hoffmann hh. Nature. 2024 Dec 11. doi: 10.1038/s41586-024-08320-0. Online ahead of print. Nature. 2024. PMID: 39663451
Antiviral innate immune memory in alveolar macrophages following SARS-CoV-2 infection ameliorates secondary influenza A virus disease.
Lercher A, Cheong JG, Bale MJ, Jiang C, Hoffmann HH, Ashbrook AW, Lewy T, Yin YS, Quirk C, DeGrace EJ, Chiriboga L, Rosenberg BR, Josefowicz SZ, Rice CM. Lercher A, et al. Among authors: hoffmann hh. Immunity. 2024 Nov 12;57(11):2530-2546.e13. doi: 10.1016/j.immuni.2024.08.018. Epub 2024 Sep 30. Immunity. 2024. PMID: 39353439
A genome-wide arrayed CRISPR screen identifies PLSCR1 as an intrinsic barrier to SARS-CoV-2 entry that recent virus variants have evolved to resist.
Le Pen J, Paniccia G, Kinast V, Moncada-Velez M, Ashbrook AW, Bauer M, Hoffmann HH, Pinharanda A, Ricardo-Lax I, Stenzel AF, Rosado-Olivieri EA, Dinnon KH 3rd, Doyle WC, Freije CA, Hong SH, Lee D, Lewy T, Luna JM, Peace A, Schmidt C, Schneider WM, Winkler R, Yip EZ, Larson C, McGinn T, Menezes MR, Ramos-Espiritu L, Banerjee P, Poirier JT, Sànchez-Rivera FJ, Cobat A, Zhang Q, Casanova JL, Carroll TS, Glickman JF, Michailidis E, Razooky B, MacDonald MR, Rice CM. Le Pen J, et al. Among authors: hoffmann hh. PLoS Biol. 2024 Sep 24;22(9):e3002767. doi: 10.1371/journal.pbio.3002767. eCollection 2024 Sep. PLoS Biol. 2024. PMID: 39316623 Free PMC article.
Human antibodies in Mexico and Brazil neutralizing tick-borne flaviviruses.
Cervantes Rincón T, Kapoor T, Keeffe JR, Simonelli L, Hoffmann HH, Agudelo M, Jurado A, Peace A, Lee YE, Gazumyan A, Guidetti F, Cantergiani J, Cena B, Bianchini F, Tamagnini E, Moro SG, Svoboda P, Costa F, Reis MG, Ko AI, Fallon BA, Avila-Rios S, Reyes-Téran G, Rice CM, Nussenzweig MC, Bjorkman PJ, Ruzek D, Varani L, MacDonald MR, Robbiani DF. Cervantes Rincón T, et al. Among authors: hoffmann hh. Cell Rep. 2024 Jun 25;43(6):114298. doi: 10.1016/j.celrep.2024.114298. Epub 2024 May 29. Cell Rep. 2024. PMID: 38819991 Free article.
Heteromultimeric sarbecovirus receptor binding domain immunogens primarily generate variant-specific neutralizing antibodies.
Zang T, Osei Kuffour E, Baharani VA, Canis M, Schmidt F, Da Silva J, Lercher A, Chaudhary P, Hoffmann HH, Gazumyan A, Miranda IC, MacDonald MR, Rice CM, Nussenzweig MC, Hatziioannou T, Bieniasz PD. Zang T, et al. Among authors: hoffmann hh. Proc Natl Acad Sci U S A. 2023 Dec 19;120(51):e2317367120. doi: 10.1073/pnas.2317367120. Epub 2023 Dec 14. Proc Natl Acad Sci U S A. 2023. PMID: 38096415 Free PMC article.
Antiviral innate immune memory in alveolar macrophages following SARS-CoV-2 infection.
Lercher A, Cheong JG, Jiang C, Hoffmann HH, Ashbrook AW, Yin YS, Quirk C, DeGrace EJ, Chiriboga L, Rosenberg BR, Josefowicz SZ, Rice CM. Lercher A, et al. Among authors: hoffmann hh. bioRxiv [Preprint]. 2023 Nov 27:2023.11.24.568354. doi: 10.1101/2023.11.24.568354. bioRxiv. 2023. Update in: Immunity. 2024 Nov 12;57(11):2530-2546.e13. doi: 10.1016/j.immuni.2024.08.018 PMID: 38076887 Free PMC article. Updated. Preprint.
Validation of a heat-inducible Ixodes scapularis HSP70 promoter and developing a tick-specific 3xP3 promoter sequence in ISE6 cells.
Pham M, Hoffmann HH, Kurtti TJ, Chana R, Garcia-Cruz O, Aliabadi S, Gulia-Nuss M. Pham M, et al. Among authors: hoffmann hh. bioRxiv [Preprint]. 2023 Nov 29:2023.11.29.569248. doi: 10.1101/2023.11.29.569248. bioRxiv. 2023. Update in: iScience. 2024 Jul 08;27(8):110468. doi: 10.1016/j.isci.2024.110468 PMID: 38076872 Free PMC article. Updated. Preprint.
Pan-sarbecovirus prophylaxis with human anti-ACE2 monoclonal antibodies.
Zhang F, Jenkins J, de Carvalho RVH, Nakandakari-Higa S, Chen T, Abernathy ME, Baharani VA, Nyakatura EK, Andrew D, Lebedeva IV, Lorenz IC, Hoffmann HH, Rice CM, Victora GD, Barnes CO, Hatziioannou T, Bieniasz PD. Zhang F, et al. Among authors: hoffmann hh. Nat Microbiol. 2023 Jun;8(6):1051-1063. doi: 10.1038/s41564-023-01389-9. Epub 2023 May 15. Nat Microbiol. 2023. PMID: 37188812 Free PMC article.
79 results