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Transcriptional Basis for Rhythmic Control of Hunger and Metabolism within the AgRP Neuron.
Cedernaes J, Huang W, Ramsey KM, Waldeck N, Cheng L, Marcheva B, Omura C, Kobayashi Y, Peek CB, Levine DC, Dhir R, Awatramani R, Bradfield CA, Wang XA, Takahashi JS, Mokadem M, Ahima RS, Bass J. Cedernaes J, et al. Among authors: bradfield ca. Cell Metab. 2019 May 7;29(5):1078-1091.e5. doi: 10.1016/j.cmet.2019.01.023. Epub 2019 Feb 28. Cell Metab. 2019. PMID: 30827863 Free PMC article.
Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes.
Marcheva B, Ramsey KM, Buhr ED, Kobayashi Y, Su H, Ko CH, Ivanova G, Omura C, Mo S, Vitaterna MH, Lopez JP, Philipson LH, Bradfield CA, Crosby SD, JeBailey L, Wang X, Takahashi JS, Bass J. Marcheva B, et al. Among authors: bradfield ca. Nature. 2010 Jul 29;466(7306):627-31. doi: 10.1038/nature09253. Nature. 2010. PMID: 20562852 Free PMC article.
Mop3 is an essential component of the master circadian pacemaker in mammals.
Bunger MK, Wilsbacher LD, Moran SM, Clendenin C, Radcliffe LA, Hogenesch JB, Simon MC, Takahashi JS, Bradfield CA. Bunger MK, et al. Among authors: bradfield ca. Cell. 2000 Dec 22;103(7):1009-17. doi: 10.1016/s0092-8674(00)00205-1. Cell. 2000. PMID: 11163178 Free PMC article.
Obesity in mice with adipocyte-specific deletion of clock component Arntl.
Paschos GK, Ibrahim S, Song WL, Kunieda T, Grant G, Reyes TM, Bradfield CA, Vaughan CH, Eiden M, Masoodi M, Griffin JL, Wang F, Lawson JA, Fitzgerald GA. Paschos GK, et al. Among authors: bradfield ca. Nat Med. 2012 Dec;18(12):1768-77. doi: 10.1038/nm.2979. Epub 2012 Nov 11. Nat Med. 2012. PMID: 23142819 Free PMC article.
141 results