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Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity.
von Geldern TW, Morton HE, Clark RF, Brown BS, Johnston KL, Ford L, Specht S, Carr RA, Stolarik DF, Ma J, Rieser MJ, Struever D, Frohberger SJ, Koschel M, Ehrens A, Turner JD, Hübner MP, Hoerauf A, Taylor MJ, Ward SA, Marsh K, Kempf DJ. von Geldern TW, et al. Among authors: johnston kl. PLoS Negl Trop Dis. 2019 Feb 28;13(2):e0007159. doi: 10.1371/journal.pntd.0007159. eCollection 2019 Feb. PLoS Negl Trop Dis. 2019. PMID: 30818326 Free PMC article.
Functional conservation of the lipid II biosynthesis pathway in the cell wall-less bacteria Chlamydia and Wolbachia: why is lipid II needed?
Henrichfreise B, Schiefer A, Schneider T, Nzukou E, Poellinger C, Hoffmann TJ, Johnston KL, Moelleken K, Wiedemann I, Pfarr K, Hoerauf A, Sahl HG. Henrichfreise B, et al. Among authors: johnston kl. Mol Microbiol. 2009 Sep;73(5):913-23. doi: 10.1111/j.1365-2958.2009.06815.x. Epub 2009 Jul 28. Mol Microbiol. 2009. PMID: 19656295 Free article.
Macrofilaricidal activity after doxycycline only treatment of Onchocerca volvulus in an area of Loa loa co-endemicity: a randomized controlled trial.
Turner JD, Tendongfor N, Esum M, Johnston KL, Langley RS, Ford L, Faragher B, Specht S, Mand S, Hoerauf A, Enyong P, Wanji S, Taylor MJ. Turner JD, et al. Among authors: johnston kl. PLoS Negl Trop Dis. 2010 Apr 13;4(4):e660. doi: 10.1371/journal.pntd.0000660. PLoS Negl Trop Dis. 2010. PMID: 20405054 Free PMC article. Clinical Trial.
Wolbachia filarial interactions.
Taylor MJ, Voronin D, Johnston KL, Ford L. Taylor MJ, et al. Among authors: johnston kl. Cell Microbiol. 2013 Apr;15(4):520-6. doi: 10.1111/cmi.12084. Epub 2012 Dec 24. Cell Microbiol. 2013. PMID: 23210448 Review.
89 results