Garcia KC - Search Results

1

Structure of the IFNγ receptor complex guides design of biased agonists.

Mendoza JL, Escalante NK, Jude KM, Sotolongo Bellon J, Su L, Horton TM, Tsutsumi N, Berardinelli SJ, Haltiwanger RS, Piehler J, Engleman EG, Garcia KC. Mendoza JL, et al. Among authors: garcia kc. Nature. 2019 Mar;567(7746):56-60. doi: 10.1038/s41586-019-0988-7. Epub 2019 Feb 27. Nature. 2019. PMID: 30814731 Free PMC article.

2

Two-step binding mechanism for T-cell receptor recognition of peptide MHC.

Wu LC, Tuot DS, Lyons DS, Garcia KC, Davis MM. Wu LC, et al. Among authors: garcia kc. Nature. 2002 Aug 1;418(6897):552-6. doi: 10.1038/nature00920. Nature. 2002. PMID: 12152083

3

Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'.

Feng D, Bond CJ, Ely LK, Maynard J, Garcia KC. Feng D, et al. Among authors: garcia kc. Nat Immunol. 2007 Sep;8(9):975-83. doi: 10.1038/ni1502. Epub 2007 Aug 12. Nat Immunol. 2007. PMID: 17694060

4

An autonomous CDR3delta is sufficient for recognition of the nonclassical MHC class I molecules T10 and T22 by gammadelta T cells.

Adams EJ, Strop P, Shin S, Chien YH, Garcia KC. Adams EJ, et al. Among authors: garcia kc. Nat Immunol. 2008 Jul;9(7):777-84. doi: 10.1038/ni.1620. Epub 2008 May 30. Nat Immunol. 2008. PMID: 18516039 Free PMC article.

5

The molecular basis of TCR germline bias for MHC is surprisingly simple.

Garcia KC, Adams JJ, Feng D, Ely LK. Garcia KC, et al. Nat Immunol. 2009 Feb;10(2):143-7. doi: 10.1038/ni.f.219. Nat Immunol. 2009. PMID: 19148199 Free PMC article. Review.

6

Structural basis of receptor sharing by interleukin 17 cytokines.

Ely LK, Fischer S, Garcia KC. Ely LK, et al. Among authors: garcia kc. Nat Immunol. 2009 Dec;10(12):1245-51. doi: 10.1038/ni.1813. Epub 2009 Oct 18. Nat Immunol. 2009. PMID: 19838198 Free PMC article.

7

Structural linkage between ligand discrimination and receptor activation by type I interferons.

Thomas C, Moraga I, Levin D, Krutzik PO, Podoplelova Y, Trejo A, Lee C, Yarden G, Vleck SE, Glenn JS, Nolan GP, Piehler J, Schreiber G, Garcia KC. Thomas C, et al. Among authors: garcia kc. Cell. 2011 Aug 19;146(4):621-32. doi: 10.1016/j.cell.2011.06.048. Cell. 2011. PMID: 21854986 Free PMC article.

8

T cell receptor signaling is limited by docking geometry to peptide-major histocompatibility complex.

Adams JJ, Narayanan S, Liu B, Birnbaum ME, Kruse AC, Bowerman NA, Chen W, Levin AM, Connolly JM, Zhu C, Kranz DM, Garcia KC. Adams JJ, et al. Among authors: garcia kc. Immunity. 2011 Nov 23;35(5):681-93. doi: 10.1016/j.immuni.2011.09.013. Immunity. 2011. PMID: 22101157 Free PMC article.

9

Structure of the activating IL-1 receptor signaling complex.

Thomas C, Bazan JF, Garcia KC. Thomas C, et al. Among authors: garcia kc. Nat Struct Mol Biol. 2012 Mar 18;19(4):455-7. doi: 10.1038/nsmb.2260. Nat Struct Mol Biol. 2012. PMID: 22426547 Free PMC article.

10

Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'.

Levin AM, Bates DL, Ring AM, Krieg C, Lin JT, Su L, Moraga I, Raeber ME, Bowman GR, Novick P, Pande VS, Fathman CG, Boyman O, Garcia KC. Levin AM, et al. Among authors: garcia kc. Nature. 2012 Mar 25;484(7395):529-33. doi: 10.1038/nature10975. Nature. 2012. PMID: 22446627 Free PMC article.

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