Chen L - Search Results

1

Bisulfite-free direct detection of 5-methylcytosine and 5-hydroxymethylcytosine at base resolution.

Liu Y, Siejka-Zielińska P, Velikova G, Bi Y, Yuan F, Tomkova M, Bai C, Chen L, Schuster-Böckler B, Song CX. Liu Y, et al. Among authors: chen l. Nat Biotechnol. 2019 Apr;37(4):424-429. doi: 10.1038/s41587-019-0041-2. Epub 2019 Feb 25. Nat Biotechnol. 2019. PMID: 30804537

2

Bisulfite-Free, Nanoscale Analysis of 5-Hydroxymethylcytosine at Single Base Resolution.

Zeng H, He B, Xia B, Bai D, Lu X, Cai J, Chen L, Zhou A, Zhu C, Meng H, Gao Y, Guo H, He C, Dai Q, Yi C. Zeng H, et al. Among authors: chen l. J Am Chem Soc. 2018 Oct 17;140(41):13190-13194. doi: 10.1021/jacs.8b08297. Epub 2018 Oct 4. J Am Chem Soc. 2018. PMID: 30278133 Free PMC article.

3

Structural insights into the mechanism of human soluble guanylate cyclase.

Kang Y, Liu R, Wu JX, Chen L. Kang Y, et al. Among authors: chen l. Nature. 2019 Oct;574(7777):206-210. doi: 10.1038/s41586-019-1584-6. Epub 2019 Sep 12. Nature. 2019. PMID: 31514202

4

Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor.

Guan C, Niu Y, Chen SC, Kang Y, Wu JX, Nishi K, Chang CCY, Chang TY, Luo T, Chen L. Guan C, et al. Among authors: chen sc, chen l. Nat Commun. 2020 May 18;11(1):2478. doi: 10.1038/s41467-020-16288-4. Nat Commun. 2020. PMID: 32424158 Free PMC article.

5

Structural basis of inhibition of the human SGLT2-MAP17 glucose transporter.

Niu Y, Liu R, Guan C, Zhang Y, Chen Z, Hoerer S, Nar H, Chen L. Niu Y, et al. Among authors: chen z, chen l. Nature. 2022 Jan;601(7892):280-284. doi: 10.1038/s41586-021-04212-9. Epub 2021 Dec 8. Nature. 2022. PMID: 34880493

6

Structural mechanism of SGLT1 inhibitors.

Niu Y, Cui W, Liu R, Wang S, Ke H, Lei X, Chen L. Niu Y, et al. Among authors: chen l. Nat Commun. 2022 Oct 28;13(1):6440. doi: 10.1038/s41467-022-33421-7. Nat Commun. 2022. PMID: 36307403 Free PMC article.

7

Structural basis for the binding of DNP and purine nucleotides onto UCP1.

Kang Y, Chen L. Kang Y, et al. Among authors: chen l. Nature. 2023 Aug;620(7972):226-231. doi: 10.1038/s41586-023-06332-w. Epub 2023 Jun 19. Nature. 2023. PMID: 37336486

8

Structure of human phagocyte NADPH oxidase in the activated state.

Liu X, Shi Y, Liu R, Song K, Chen L. Liu X, et al. Among authors: chen l. Nature. 2024 Mar;627(8002):189-195. doi: 10.1038/s41586-024-07056-1. Epub 2024 Feb 14. Nature. 2024. PMID: 38355798

9

Conserved regulatory elements in AMPK.

Chen L, Xin FJ, Wang J, Hu J, Zhang YY, Wan S, Cao LS, Lu C, Li P, Yan SF, Neumann D, Schlattner U, Xia B, Wang ZX, Wu JW. Chen L, et al. Nature. 2013 Jun 13;498(7453):E8-10. doi: 10.1038/nature12189. Nature. 2013. PMID: 23765502 No abstract available.

10

Structural insight into the mechanism of synergistic autoinhibition of SAD kinases.

Wu JX, Cheng YS, Wang J, Chen L, Ding M, Wu JW. Wu JX, et al. Among authors: chen l. Nat Commun. 2015 Dec 2;6:8953. doi: 10.1038/ncomms9953. Nat Commun. 2015. PMID: 26626945 Free PMC article.

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