Newton AC - Search Results

1

Apical-basal polarity inhibits epithelial-mesenchymal transition and tumour metastasis by PAR-complex-mediated SNAI1 degradation.

Jung HY, Fattet L, Tsai JH, Kajimoto T, Chang Q, Newton AC, Yang J. Jung HY, et al. Among authors: newton ac. Nat Cell Biol. 2019 Mar;21(3):359-371. doi: 10.1038/s41556-019-0291-8. Epub 2019 Feb 25. Nat Cell Biol. 2019. PMID: 30804505 Free PMC article.

2

The protein scaffold NHERF-1 controls the amplitude and duration of localized protein kinase D activity.

Kunkel MT, Garcia EL, Kajimoto T, Hall RA, Newton AC. Kunkel MT, et al. Among authors: newton ac. J Biol Chem. 2009 Sep 4;284(36):24653-61. doi: 10.1074/jbc.M109.024547. Epub 2009 Jul 6. J Biol Chem. 2009. PMID: 19581308 Free PMC article.

3

Protein kinase C {delta}-specific activity reporter reveals agonist-evoked nuclear activity controlled by Src family of kinases.

Kajimoto T, Sawamura S, Tohyama Y, Mori Y, Newton AC. Kajimoto T, et al. Among authors: newton ac. J Biol Chem. 2010 Dec 31;285(53):41896-910. doi: 10.1074/jbc.M110.184028. Epub 2010 Oct 19. J Biol Chem. 2010. PMID: 20959447 Free PMC article.

4

Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor.

Antal CE, Hudson AM, Kang E, Zanca C, Wirth C, Stephenson NL, Trotter EW, Gallegos LL, Miller CJ, Furnari FB, Hunter T, Brognard J, Newton AC. Antal CE, et al. Among authors: newton ac. Cell. 2015 Jan 29;160(3):489-502. doi: 10.1016/j.cell.2015.01.001. Epub 2015 Jan 22. Cell. 2015. PMID: 25619690 Free PMC article.

5

Activation of atypical protein kinase C by sphingosine 1-phosphate revealed by an aPKC-specific activity reporter.

Kajimoto T, Caliman AD, Tobias IS, Okada T, Pilo CA, Van AN, Andrew McCammon J, Nakamura SI, Newton AC. Kajimoto T, et al. Among authors: newton ac. Sci Signal. 2019 Jan 1;12(562):eaat6662. doi: 10.1126/scisignal.aat6662. Sci Signal. 2019. PMID: 30600259 Free PMC article.

6

The PHLPP2 phosphatase is a druggable driver of prostate cancer progression.

Nowak DG, Katsenelson KC, Watrud KE, Chen M, Mathew G, D'Andrea VD, Lee MF, Swamynathan MM, Casanova-Salas I, Jibilian MC, Buckholtz CL, Ambrico AJ, Pan CH, Wilkinson JE, Newton AC, Trotman LC. Nowak DG, et al. Among authors: newton ac. J Cell Biol. 2019 Jun 3;218(6):1943-1957. doi: 10.1083/jcb.201902048. Epub 2019 May 15. J Cell Biol. 2019. PMID: 31092557 Free PMC article.

7

Sensitive fluorescent biosensor reveals differential subcellular regulation of PKC.

Su Q, Zhang J, Lin W, Zhang JF, Newton AC, Mehta S, Yang J, Zhang J. Su Q, et al. Among authors: newton ac. Nat Chem Biol. 2024 Oct 11. doi: 10.1038/s41589-024-01758-3. Online ahead of print. Nat Chem Biol. 2024. PMID: 39394268

8

Protein kinase C: ports of anchor in the cell.

Newton AC. Newton AC. Curr Biol. 1996 Jul 1;6(7):806-9. doi: 10.1016/s0960-9822(02)00600-0. Curr Biol. 1996. PMID: 8805297 Free article. Review.

9

A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C.

Violin JD, Zhang J, Tsien RY, Newton AC. Violin JD, et al. Among authors: newton ac. J Cell Biol. 2003 Jun 9;161(5):899-909. doi: 10.1083/jcb.200302125. Epub 2003 Jun 2. J Cell Biol. 2003. PMID: 12782683 Free PMC article.

10

PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth.

Gao T, Furnari F, Newton AC. Gao T, et al. Among authors: newton ac. Mol Cell. 2005 Apr 1;18(1):13-24. doi: 10.1016/j.molcel.2005.03.008. Mol Cell. 2005. PMID: 15808505 Free article.

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