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The Dual PI3K/mTOR Pathway Inhibitor GDC-0084 Achieves Antitumor Activity in PIK3CA-Mutant Breast Cancer Brain Metastases.
Ippen FM, Alvarez-Breckenridge CA, Kuter BM, Fink AL, Bihun IV, Lastrapes M, Penson T, Schmidt SP, Wojtkiewicz GR, Ning J, Subramanian M, Giobbie-Hurder A, Martinez-Lage M, Carter SL, Cahill DP, Wakimoto H, Brastianos PK. Ippen FM, et al. Among authors: wojtkiewicz gr. Clin Cancer Res. 2019 Jun 1;25(11):3374-3383. doi: 10.1158/1078-0432.CCR-18-3049. Epub 2019 Feb 22. Clin Cancer Res. 2019. PMID: 30796030 Free PMC article.
Combined MEK and PI3K inhibition in a mouse model of pancreatic cancer.
Alagesan B, Contino G, Guimaraes AR, Corcoran RB, Deshpande V, Wojtkiewicz GR, Hezel AF, Wong KK, Loda M, Weissleder R, Benes CH, Engelman J, Bardeesy N. Alagesan B, et al. Among authors: wojtkiewicz gr. Clin Cancer Res. 2015 Jan 15;21(2):396-404. doi: 10.1158/1078-0432.CCR-14-1591. Epub 2014 Oct 27. Clin Cancer Res. 2015. PMID: 25348516 Free PMC article.
Genotype-targeted local therapy of glioma.
Shankar GM, Kirtane AR, Miller JJ, Mazdiyasni H, Rogner J, Tai T, Williams EA, Higuchi F, Juratli TA, Tateishi K, Koerner MVA, Tummala SS, Fink AL, Penson T, Schmidt SP, Wojtkiewicz GR, Baig A, Francis JM, Rinne ML, Batten JM, Batchelor TT, Brastianos PK, Curry WT Jr, Barker FG 2nd, Jordan JT, Iafrate AJ, Chi AS, Lennerz JK, Meyerson M, Langer R, Wakimoto H, Traverso G, Cahill DP. Shankar GM, et al. Among authors: wojtkiewicz gr. Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):E8388-E8394. doi: 10.1073/pnas.1805751115. Epub 2018 Aug 6. Proc Natl Acad Sci U S A. 2018. PMID: 30082399 Free PMC article.
Nanoparticle-encapsulated siRNAs for gene silencing in the haematopoietic stem-cell niche.
Krohn-Grimberghe M, Mitchell MJ, Schloss MJ, Khan OF, Courties G, Guimaraes PPG, Rohde D, Cremer S, Kowalski PS, Sun Y, Tan M, Webster J, Wang K, Iwamoto Y, Schmidt SP, Wojtkiewicz GR, Nayar R, Frodermann V, Hulsmans M, Chung A, Hoyer FF, Swirski FK, Langer R, Anderson DG, Nahrendorf M. Krohn-Grimberghe M, et al. Among authors: wojtkiewicz gr. Nat Biomed Eng. 2020 Nov;4(11):1076-1089. doi: 10.1038/s41551-020-00623-7. Epub 2020 Oct 5. Nat Biomed Eng. 2020. PMID: 33020600 Free PMC article.
Highly Efficient Activatable MRI Probe to Sense Myeloperoxidase Activity.
Wang C, Cheng D, Jalali Motlagh N, Kuellenberg EG, Wojtkiewicz GR, Schmidt SP, Stocker R, Chen JW. Wang C, et al. Among authors: wojtkiewicz gr. J Med Chem. 2021 May 13;64(9):5874-5885. doi: 10.1021/acs.jmedchem.1c00038. Epub 2021 May 4. J Med Chem. 2021. PMID: 33945286 Free PMC article.
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