Geva M - Search Results

1

Pridopidine Induces Functional Neurorestoration Via the Sigma-1 Receptor in a Mouse Model of Parkinson's Disease.

Francardo V, Geva M, Bez F, Denis Q, Steiner L, Hayden MR, Cenci MA. Francardo V, et al. Among authors: geva m. Neurotherapeutics. 2019 Apr;16(2):465-479. doi: 10.1007/s13311-018-00699-9. Neurotherapeutics. 2019. PMID: 30756361 Free PMC article.

2

Pridopidine activates neuroprotective pathways impaired in Huntington Disease.

Geva M, Kusko R, Soares H, Fowler KD, Birnberg T, Barash S, -Wagner AM, Fine T, Lysaght A, Weiner B, Cha Y, Kolitz S, Towfic F, Orbach A, Laufer R, Zeskind B, Grossman I, Hayden MR. Geva M, et al. Hum Mol Genet. 2016 Sep 15;25(18):3975-3987. doi: 10.1093/hmg/ddw238. Epub 2016 Jul 27. Hum Mol Genet. 2016. PMID: 27466197 Free PMC article.

3

The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease.

Ryskamp D, Wu J, Geva M, Kusko R, Grossman I, Hayden M, Bezprozvanny I. Ryskamp D, et al. Among authors: geva m. Neurobiol Dis. 2017 Jan;97(Pt A):46-59. doi: 10.1016/j.nbd.2016.10.006. Epub 2016 Nov 3. Neurobiol Dis. 2017. PMID: 27818324 Free PMC article.

4

Early pridopidine treatment improves behavioral and transcriptional deficits in YAC128 Huntington disease mice.

Garcia-Miralles M, Geva M, Tan JY, Yusof NABM, Cha Y, Kusko R, Tan LJ, Xu X, Grossman I, Orbach A, Hayden MR, Pouladi MA. Garcia-Miralles M, et al. Among authors: geva m. JCI Insight. 2017 Dec 7;2(23):e95665. doi: 10.1172/jci.insight.95665. JCI Insight. 2017. PMID: 29212949 Free PMC article.

5

Large-scale transcriptomic analysis reveals that pridopidine reverses aberrant gene expression and activates neuroprotective pathways in the YAC128 HD mouse.

Kusko R, Dreymann J, Ross J, Cha Y, Escalante-Chong R, Garcia-Miralles M, Tan LJ, Burczynski ME, Zeskind B, Laifenfeld D, Pouladi M, Geva M, Grossman I, Hayden MR. Kusko R, et al. Among authors: geva m. Mol Neurodegener. 2018 May 21;13(1):25. doi: 10.1186/s13024-018-0259-3. Mol Neurodegener. 2018. PMID: 29783994 Free PMC article.

6

Pridopidine, a clinic-ready compound, reduces 3,4-dihydroxyphenylalanine-induced dyskinesia in Parkinsonian macaques.

Johnston TH, Geva M, Steiner L, Orbach A, Papapetropoulos S, Savola JM, Reynolds IJ, Ravenscroft P, Hill M, Fox SH, Brotchie JM, Laufer R, Hayden MR. Johnston TH, et al. Among authors: geva m. Mov Disord. 2019 May;34(5):708-716. doi: 10.1002/mds.27565. Epub 2018 Dec 21. Mov Disord. 2019. PMID: 30575996

7

Pridopidine stabilizes mushroom spines in mouse models of Alzheimer's disease by acting on the sigma-1 receptor.

Ryskamp D, Wu L, Wu J, Kim D, Rammes G, Geva M, Hayden M, Bezprozvanny I. Ryskamp D, et al. Among authors: geva m. Neurobiol Dis. 2019 Apr;124:489-504. doi: 10.1016/j.nbd.2018.12.022. Epub 2018 Dec 27. Neurobiol Dis. 2019. PMID: 30594810 Free PMC article.

8

Targeting the Sigma-1 Receptor via Pridopidine Ameliorates Central Features of ALS Pathology in a SOD1^G93A Model.

Ionescu A, Gradus T, Altman T, Maimon R, Saraf Avraham N, Geva M, Hayden M, Perlson E. Ionescu A, et al. Among authors: geva m. Cell Death Dis. 2019 Mar 1;10(3):210. doi: 10.1038/s41419-019-1451-2. Cell Death Dis. 2019. PMID: 30824685 Free PMC article.

9

Pridopidine protects neurons from mutant-huntingtin toxicity via the sigma-1 receptor.

Eddings CR, Arbez N, Akimov S, Geva M, Hayden MR, Ross CA. Eddings CR, et al. Among authors: geva m. Neurobiol Dis. 2019 Sep;129:118-129. doi: 10.1016/j.nbd.2019.05.009. Epub 2019 May 17. Neurobiol Dis. 2019. PMID: 31108174 Free PMC article.

10

Impairment and Restoration of Homeostatic Plasticity in Cultured Cortical Neurons From a Mouse Model of Huntington Disease.

Smith-Dijak AI, Nassrallah WB, Zhang LYJ, Geva M, Hayden MR, Raymond LA. Smith-Dijak AI, et al. Among authors: geva m. Front Cell Neurosci. 2019 May 16;13:209. doi: 10.3389/fncel.2019.00209. eCollection 2019. Front Cell Neurosci. 2019. PMID: 31156395 Free PMC article.

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