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Engineered botulinum neurotoxin B with improved binding to human receptors has enhanced efficacy in preclinical models.
Elliott M, Favre-Guilmard C, Liu SM, Maignel J, Masuyer G, Beard M, Boone C, Carré D, Kalinichev M, Lezmi S, Mir I, Nicoleau C, Palan S, Perier C, Raban E, Zhang S, Dong M, Stenmark P, Krupp J. Elliott M, et al. Sci Adv. 2019 Jan 16;5(1):eaau7196. doi: 10.1126/sciadv.aau7196. eCollection 2019 Jan. Sci Adv. 2019. PMID: 30746458 Free PMC article.
A comparison of biological activity of commercially available purified native botulinum neurotoxin serotypes A1 to F1 in vitro, ex vivo, and in vivo.
Donald S, Elliott M, Gray B, Hornby F, Lewandowska A, Marlin S, Favre-Guilmard C, Périer C, Cornet S, Kalinichev M, Krupp J, Fonfria E. Donald S, et al. Among authors: elliott m. Pharmacol Res Perspect. 2018 Nov 22;6(6):e00446. doi: 10.1002/prp2.446. eCollection 2018 Dec. Pharmacol Res Perspect. 2018. PMID: 30519475 Free PMC article.
Structure and activity of botulinum neurotoxin X.
Martínez-Carranza M, Škerlová J, Lee PG, Zhang J, Burgin D, Elliott M, Philippe J, Donald S, Hornby F, Henriksson L, Masuyer G, Beard M, Dong M, Stenmark P. Martínez-Carranza M, et al. Among authors: elliott m. bioRxiv [Preprint]. 2023 Jan 11:2023.01.11.523524. doi: 10.1101/2023.01.11.523524. bioRxiv. 2023. PMID: 36712025 Free PMC article. Preprint.
Activity of botulinum neurotoxin X and its structure when shielded by a non-toxic non-hemagglutinin protein.
Martínez-Carranza M, Škerlová J, Lee PG, Zhang J, Krč A, Sirohiwal A, Burgin D, Elliott M, Philippe J, Donald S, Hornby F, Henriksson L, Masuyer G, Kaila VRI, Beard M, Dong M, Stenmark P. Martínez-Carranza M, et al. Among authors: elliott m. Commun Chem. 2024 Aug 13;7(1):179. doi: 10.1038/s42004-024-01262-8. Commun Chem. 2024. PMID: 39138288 Free PMC article.
3,224 results