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Discovery of novel dual-active 3-(4-(dimethylamino)phenyl)-7-aminoalcoxy-coumarin as potent and selective acetylcholinesterase inhibitor and antioxidant.
de Souza GA, da Silva SJ, Del Cistia CN, Pitasse-Santos P, Pires LO, Passos YM, Cordeiro Y, Cardoso CM, Castro RN, Sant'Anna CMR, Kümmerle AE. de Souza GA, et al. Among authors: kummerle ae. J Enzyme Inhib Med Chem. 2019 Dec;34(1):631-637. doi: 10.1080/14756366.2019.1571270. J Enzyme Inhib Med Chem. 2019. PMID: 30727776 Free PMC article.
Design, synthesis, and pharmacological evaluation of N-acylhydrazones and novel conformationally constrained compounds as selective and potent orally active phosphodiesterase-4 inhibitors.
Kümmerle AE, Schmitt M, Cardozo SV, Lugnier C, Villa P, Lopes AB, Romeiro NC, Justiniano H, Martins MA, Fraga CA, Bourguignon JJ, Barreiro EJ. Kümmerle AE, et al. J Med Chem. 2012 Sep 13;55(17):7525-45. doi: 10.1021/jm300514y. Epub 2012 Aug 30. J Med Chem. 2012. PMID: 22891752
Synthesis and Evaluation of Antiproliferative Activity, Topoisomerase IIα Inhibition, DNA Binding and Non-Clinical Toxicity of New Acridine-Thiosemicarbazone Derivatives.
Sousa G, de Almeida MCF, Lócio LL, Dos Santos VL, Bezerra DP, Silva VR, de Almeida SMV, Simon A, Honório TDS, Cabral LM, Castro RN, de Moura RO, Kümmerle AE. Sousa G, et al. Among authors: kummerle ae. Pharmaceuticals (Basel). 2022 Sep 2;15(9):1098. doi: 10.3390/ph15091098. Pharmaceuticals (Basel). 2022. PMID: 36145320 Free PMC article.
Discovery of novel thiosemicarbazone-acridine targeting butyrylcholinesterase with antioxidant, metal complexing and neuroprotector abilities as potential treatment of Alzheimer's disease: In vitro, in vivo, and in silico studies.
Silva Sousa GL, Nadur NF, de Almeida Peixoto Ferreira L, da Silva Honório T, Simon A, Cabral LM, Móra Santos ML, Andrade B, de Lima EV, Clarke JR, Castro RN, Olímpio de Moura R, Kümmerle AE. Silva Sousa GL, et al. Among authors: kummerle ae. Eur J Med Chem. 2025 Jan 5;281:117030. doi: 10.1016/j.ejmech.2024.117030. Epub 2024 Nov 7. Eur J Med Chem. 2025. PMID: 39531933
39 results