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Page 1
RABL6A inhibits tumor-suppressive PP2A/AKT signaling to drive pancreatic neuroendocrine tumor growth.
Umesalma S, Kaemmer CA, Kohlmeyer JL, Letney B, Schab AM, Reilly JA, Sheehy RM, Hagen J, Tiwari N, Zhan F, Leidinger MR, O'Dorisio TM, Dillon J, Merrill RA, Meyerholz DK, Perl AL, Brown BJ, Braun TA, Scott AT, Ginader T, Taghiyev AF, Zamba GK, Howe JR, Strack S, Bellizzi AM, Narla G, Darbro BW, Quelle FW, Quelle DE. Umesalma S, et al. Among authors: kaemmer ca. J Clin Invest. 2019 Mar 4;129(4):1641-1653. doi: 10.1172/JCI123049. eCollection 2019 Mar 4. J Clin Invest. 2019. PMID: 30721156 Free PMC article.
Gene Expression Signatures Identify Novel Therapeutics for Metastatic Pancreatic Neuroendocrine Tumors.
Scott AT, Weitz M, Breheny PJ, Ear PH, Darbro B, Brown BJ, Braun TA, Li G, Umesalma S, Kaemmer CA, Maharjan CK, Quelle DE, Bellizzi AM, Chandrasekharan C, Dillon JS, O'Dorisio TM, Howe JR. Scott AT, et al. Among authors: kaemmer ca. Clin Cancer Res. 2020 Apr 15;26(8):2011-2021. doi: 10.1158/1078-0432.CCR-19-2884. Epub 2020 Jan 14. Clin Cancer Res. 2020. PMID: 31937620 Free PMC article.
RABL6A Is an Essential Driver of MPNSTs that Negatively Regulates the RB1 Pathway and Sensitizes Tumor Cells to CDK4/6 Inhibitors.
Kohlmeyer JL, Kaemmer CA, Pulliam C, Maharjan CK, Samayoa AM, Major HJ, Cornick KE, Knepper-Adrian V, Khanna R, Sieren JC, Leidinger MR, Meyerholz DK, Zamba KD, Weimer JM, Dodd RD, Darbro BW, Tanas MR, Quelle DE. Kohlmeyer JL, et al. Among authors: kaemmer ca. Clin Cancer Res. 2020 Jun 15;26(12):2997-3011. doi: 10.1158/1078-0432.CCR-19-2706. Epub 2020 Feb 21. Clin Cancer Res. 2020. PMID: 32086342 Free PMC article.
RABL6A Regulates Schwann Cell Senescence in an RB1-Dependent Manner.
Kohlmeyer JL, Kaemmer CA, Umesalma S, Gourronc FA, Klingelhutz AJ, Quelle DE. Kohlmeyer JL, et al. Among authors: kaemmer ca. Int J Mol Sci. 2021 May 20;22(10):5367. doi: 10.3390/ijms22105367. Int J Mol Sci. 2021. PMID: 34065204 Free PMC article.
RABL6A Promotes Pancreatic Neuroendocrine Tumor Angiogenesis and Progression In Vivo.
Maharjan CK, Umesalma S, Kaemmer CA, Muniz VP, Bauchle C, Mott SL, Zamba KD, Breheny P, Leidinger MR, Darbro BW, Stephens SB, Meyerholz DK, Quelle DE. Maharjan CK, et al. Among authors: kaemmer ca. Biomedicines. 2021 Jun 2;9(6):633. doi: 10.3390/biomedicines9060633. Biomedicines. 2021. PMID: 34199469 Free PMC article.
Oncogenic RABL6A promotes NF1-associated MPNST progression in vivo.
Kohlmeyer JL, Kaemmer CA, Lingo JJ, Voigt E, Leidinger MR, McGivney GR, Scherer A, Koppenhafer SL, Gordon DJ, Breheny P, Meyerholz DK, Tanas MR, Dodd RD, Quelle DE. Kohlmeyer JL, et al. Among authors: kaemmer ca. Neurooncol Adv. 2022 Apr 9;4(1):vdac047. doi: 10.1093/noajnl/vdac047. eCollection 2022 Jan-Dec. Neurooncol Adv. 2022. PMID: 35571990 Free PMC article.
CDK4/6-MEK Inhibition in MPNSTs Causes Plasma Cell Infiltration, Sensitization to PD-L1 Blockade, and Tumor Regression.
Kohlmeyer JL, Lingo JJ, Kaemmer CA, Scherer A, Warrier A, Voigt E, Raygoza Garay JA, McGivney GR, Brockman QR, Tang A, Calizo A, Pollard K, Zhang X, Hirbe AC, Pratilas CA, Leidinger M, Breheny P, Chimenti MS, Sieren JC, Monga V, Tanas MR, Meyerholz DK, Darbro BW, Dodd RD, Quelle DE. Kohlmeyer JL, et al. Among authors: kaemmer ca. Clin Cancer Res. 2023 Sep 1;29(17):3484-3497. doi: 10.1158/1078-0432.CCR-23-0749. Clin Cancer Res. 2023. PMID: 37410426 Free PMC article.
Inhibition of serotonin biosynthesis in neuroendocrine neoplasm suppresses tumor growth in vivo.
Tow DH, Tran CG, Borbon LC, Ridder M, Li G, Kaemmer CA, Abusada E, Mahalingam AH, Sadanandam A, Chandrasekaran C, Dillon J, Spitz DR, Quelle DE, Chan CHF, Bellizzi A, Howe JR, Ear PH. Tow DH, et al. Among authors: kaemmer ca. bioRxiv [Preprint]. 2023 Apr 8:2023.04.07.536013. doi: 10.1101/2023.04.07.536013. bioRxiv. 2023. PMID: 37066322 Free PMC article. Preprint.