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Page 1
DDX3X Helicase Inhibitors as a New Strategy To Fight the West Nile Virus Infection.
Brai A, Martelli F, Riva V, Garbelli A, Fazi R, Zamperini C, Pollutri A, Falsitta L, Ronzini S, Maccari L, Maga G, Giannecchini S, Botta M. Brai A, et al. Among authors: garbelli a. J Med Chem. 2019 Mar 14;62(5):2333-2347. doi: 10.1021/acs.jmedchem.8b01403. Epub 2019 Feb 21. J Med Chem. 2019. PMID: 30721061
Mutational analysis of the HIV-1 auxiliary protein Vif identifies independent domains important for the physical and functional interaction with HIV-1 reverse transcriptase.
Kataropoulou A, Bovolenta C, Belfiore A, Trabatti S, Garbelli A, Porcellini S, Lupo R, Maga G. Kataropoulou A, et al. Among authors: garbelli a. Nucleic Acids Res. 2009 Jun;37(11):3660-9. doi: 10.1093/nar/gkp226. Epub 2009 Apr 15. Nucleic Acids Res. 2009. PMID: 19369217 Free PMC article.
Toward the discovery of novel anti-HIV drugs. Second-generation inhibitors of the cellular ATPase DDX3 with improved anti-HIV activity: synthesis, structure-activity relationship analysis, cytotoxicity studies, and target validation.
Maga G, Falchi F, Radi M, Botta L, Casaluce G, Bernardini M, Irannejad H, Manetti F, Garbelli A, Samuele A, Zanoli S, Esté JA, Gonzalez E, Zucca E, Paolucci S, Baldanti F, De Rijck J, Debyser Z, Botta M. Maga G, et al. Among authors: garbelli a. ChemMedChem. 2011 Aug 1;6(8):1371-89. doi: 10.1002/cmdc.201100166. Epub 2011 Jun 22. ChemMedChem. 2011. PMID: 21698775
The PDZ-ligand and Src-homology type 3 domains of epidemic avian influenza virus NS1 protein modulate human Src kinase activity during viral infection.
Bavagnoli L, Dundon WG, Garbelli A, Zecchin B, Milani A, Parakkal G, Baldanti F, Paolucci S, Volmer R, Tu Y, Wu C, Capua I, Maga G. Bavagnoli L, et al. Among authors: garbelli a. PLoS One. 2011;6(11):e27789. doi: 10.1371/journal.pone.0027789. Epub 2011 Nov 14. PLoS One. 2011. PMID: 22110760 Free PMC article.
Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: towards the next generation HIV-1 inhibitors.
Radi M, Falchi F, Garbelli A, Samuele A, Bernardo V, Paolucci S, Baldanti F, Schenone S, Manetti F, Maga G, Botta M. Radi M, et al. Among authors: garbelli a. Bioorg Med Chem Lett. 2012 Mar 1;22(5):2094-8. doi: 10.1016/j.bmcl.2011.12.135. Epub 2012 Jan 8. Bioorg Med Chem Lett. 2012. PMID: 22300661
The power of enzyme kinetics in the drug development process.
Samuele A, Crespan E, Garbelli A, Bavagnoli L, Maga G. Samuele A, et al. Among authors: garbelli a. Curr Pharm Biotechnol. 2013;14(5):551-60. doi: 10.2174/138920101405131111105023. Curr Pharm Biotechnol. 2013. PMID: 22429137 Review.
26 results