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Biglycan evokes autophagy in macrophages via a novel CD44/Toll-like receptor 4 signaling axis in ischemia/reperfusion injury.
Poluzzi C, Nastase MV, Zeng-Brouwers J, Roedig H, Hsieh LT, Michaelis JB, Buhl EM, Rezende F, Manavski Y, Bleich A, Boor P, Brandes RP, Pfeilschifter J, Stelzer EHK, Münch C, Dikic I, Brandts C, Iozzo RV, Wygrecka M, Schaefer L. Poluzzi C, et al. Among authors: wygrecka m. Kidney Int. 2019 Mar;95(3):540-562. doi: 10.1016/j.kint.2018.10.037. Epub 2019 Jan 31. Kidney Int. 2019. PMID: 30712922 Free article.
Lung Fibrosis Is Linked to Increased Endothelial Cell Activation and Dysfunctional Vascular Barrier Integrity.
Fließer E, Jandl K, Lins T, Birnhuber A, Valzano F, Kolb D, Foris V, Heinemann A, Olschewski H, Evermann M, Hoetzenecker K, Kreuter M, Voelkel NF, Marsh LM, Wygrecka M, Kwapiszewska G. Fließer E, et al. Among authors: wygrecka m. Am J Respir Cell Mol Biol. 2024 Sep;71(3):318-331. doi: 10.1165/rcmb.2024-0046OC. Am J Respir Cell Mol Biol. 2024. PMID: 38843440
Evidence for a lipofibroblast-to- Cthrc1 + myofibroblast reversible switch during the development and resolution of lung fibrosis in young mice.
Lingampally A, Truchi M, Mauduit O, Delcroix V, Vasquez-Pacheco E, Gautier-Isola M, Chu X, Khadim A, Chao CM, Zabihi M, Taghizadeh S, Rivetti S, Marega M, Moiseenko A, Hadzic S, Vazquez-Armendariz AI, Herold S, Günther S, Millar-Büchner P, Koepke J, Samakovlis C, Wilhelm J, Bartkuhn M, Braun T, Weissmann N, Zhang J, Wygrecka M, Makarenkova HP, Günther A, Seeger W, Chen C, El Agha E, Mari B, Bellusci S. Lingampally A, et al. Among authors: wygrecka m. Eur Respir J. 2024 Nov 21:2300482. doi: 10.1183/13993003.00482-2023. Online ahead of print. Eur Respir J. 2024. PMID: 39401861 Free article.
Publisher Correction: Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon.
Ryan TAJ, Hooftman A, Rehill AM, Johansen MD, O' Brien EC, Toller-Kawahisa JE, Wilk MM, Day EA, Weiss HJ, Sarvari P, Vozza EG, Schramm F, Peace CG, Zotta A, Miemczyk S, Nalkurthi C, Hansbro NG, McManus G, O'Doherty L, Gargan S, Long A, Dunne J, Cheallaigh CN, Conlon N, Carty M, Fallon PG, Mills KHG, Creagh EM, O' Donnell JS, Hertzog PJ, Hansbro PM, McLoughlin RM, Wygrecka M, Preston RJS, Zasłona Z, O'Neill LAJ. Ryan TAJ, et al. Among authors: wygrecka m. Nat Commun. 2023 Jul 20;14(1):4374. doi: 10.1038/s41467-023-40034-1. Nat Commun. 2023. PMID: 37474527 Free PMC article. No abstract available.
Pentastatin, a matrikine of the collagen IVα5, is a novel endogenous mediator of pulmonary endothelial dysfunction.
Mutgan AC, Jandl K, Radic N, Valzano F, Kolb D, Hoffmann J, Foris V, Wilhelm J, Boehm PM, Hoetzenecker K, Olschewski A, Olschewski H, Heinemann A, Wygrecka M, Marsh LM, Kwapiszewska G. Mutgan AC, et al. Among authors: wygrecka m. Am J Physiol Cell Physiol. 2023 Nov 1;325(5):C1294-C1312. doi: 10.1152/ajpcell.00391.2023. Epub 2023 Sep 11. Am J Physiol Cell Physiol. 2023. PMID: 37694286 Free PMC article.
Pirfenidone exerts antifibrotic effects through inhibition of GLI transcription factors.
Didiasova M, Singh R, Wilhelm J, Kwapiszewska G, Wujak L, Zakrzewicz D, Schaefer L, Markart P, Seeger W, Lauth M, Wygrecka M. Didiasova M, et al. Among authors: wygrecka m. FASEB J. 2017 May;31(5):1916-1928. doi: 10.1096/fj.201600892RR. Epub 2017 Feb 1. FASEB J. 2017. PMID: 28148565
Because GLI transcription factors are not only crucial for Hh-mediated changes but are also required as mediators of TGF-beta signaling, our findings suggest that pirfenidone exerts its clinically beneficial effects through dual Hh/TGF-beta inhibition by targeting the GLI2 protei …
Because GLI transcription factors are not only crucial for Hh-mediated changes but are also required as mediators of TGF-beta signaling, our …
128 results