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Synthesis of sulfadiazinyl acyl/aryl thiourea derivatives as calf intestinal alkaline phosphatase inhibitors, pharmacokinetic properties, lead optimization, Lineweaver-Burk plot evaluation and binding analysis.
Sajid-Ur-Rehman, Saeed A, Saddique G, Ali Channar P, Ali Larik F, Abbas Q, Hassan M, Raza H, Fattah TA, Seo SY. Sajid-Ur-Rehman, et al. Among authors: seo sy. Bioorg Med Chem. 2018 Jul 23;26(12):3707-3715. doi: 10.1016/j.bmc.2018.06.002. Epub 2018 Jun 2. Bioorg Med Chem. 2018. PMID: 29884581
1-(2-Hydroxy-5-((trimethylsilyl)ethynyl)phenyl)ethanone based α,β-unsaturated derivatives an alternate to non-sulfonamide carbonic anhydrase II inhibitors, synthesis via Sonogashira coupling, binding analysis, Lipinsk's rule validation.
Mahar J, Saeed A, Belfield KD, Ali Larik F, Ali Channar P, Ali Kazi M, Abbas Q, Hassan M, Raza H, Seo SY. Mahar J, et al. Among authors: seo sy. Bioorg Chem. 2019 Mar;84:170-176. doi: 10.1016/j.bioorg.2018.11.031. Epub 2018 Nov 24. Bioorg Chem. 2019. PMID: 30502628
422 results