Cowen LE - Search Results

1

Genetic Analysis of Candida auris Implicates Hsp90 in Morphogenesis and Azole Tolerance and Cdr1 in Azole Resistance.

Kim SH, Iyer KR, Pardeshi L, Muñoz JF, Robbins N, Cuomo CA, Wong KH, Cowen LE. Kim SH, et al. Among authors: cowen le. mBio. 2019 Jan 29;10(1):e02529-18. doi: 10.1128/mBio.02529-18. mBio. 2019. PMID: 30696744 Free PMC article.

2

Evolution of drug resistance in Candida albicans.

Cowen LE, Anderson JB, Kohn LM. Cowen LE, et al. Annu Rev Microbiol. 2002;56:139-65. doi: 10.1146/annurev.micro.56.012302.160907. Epub 2002 Jan 30. Annu Rev Microbiol. 2002. PMID: 12142485 Review.

3

Genetic architecture of Hsp90-dependent drug resistance.

Cowen LE, Carpenter AE, Matangkasombut O, Fink GR, Lindquist S. Cowen LE, et al. Eukaryot Cell. 2006 Dec;5(12):2184-8. doi: 10.1128/EC.00274-06. Epub 2006 Oct 20. Eukaryot Cell. 2006. PMID: 17056742 Free PMC article.

4

The evolution of fungal drug resistance: modulating the trajectory from genotype to phenotype.

Cowen LE. Cowen LE. Nat Rev Microbiol. 2008 Mar;6(3):187-98. doi: 10.1038/nrmicro1835. Nat Rev Microbiol. 2008. PMID: 18246082 Review.

5

Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease.

Cowen LE, Singh SD, Köhler JR, Collins C, Zaas AK, Schell WA, Aziz H, Mylonakis E, Perfect JR, Whitesell L, Lindquist S. Cowen LE, et al. Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2818-23. doi: 10.1073/pnas.0813394106. Epub 2009 Feb 5. Proc Natl Acad Sci U S A. 2009. PMID: 19196973 Free PMC article.

6

Hsp90 orchestrates temperature-dependent Candida albicans morphogenesis via Ras1-PKA signaling.

Shapiro RS, Uppuluri P, Zaas AK, Collins C, Senn H, Perfect JR, Heitman J, Cowen LE. Shapiro RS, et al. Among authors: cowen le. Curr Biol. 2009 Apr 28;19(8):621-9. doi: 10.1016/j.cub.2009.03.017. Epub 2009 Mar 26. Curr Biol. 2009. PMID: 19327993 Free PMC article.

7

Metabolic control of antifungal drug resistance.

Robbins N, Collins C, Morhayim J, Cowen LE. Robbins N, et al. Among authors: cowen le. Fungal Genet Biol. 2010 Feb;47(2):81-93. doi: 10.1016/j.fgb.2009.07.004. Epub 2009 Jul 10. Fungal Genet Biol. 2010. PMID: 19595784

8

Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin.

Singh SD, Robbins N, Zaas AK, Schell WA, Perfect JR, Cowen LE. Singh SD, et al. Among authors: cowen le. PLoS Pathog. 2009 Jul;5(7):e1000532. doi: 10.1371/journal.ppat.1000532. Epub 2009 Jul 31. PLoS Pathog. 2009. PMID: 19649312 Free PMC article.

9

Hsp90 orchestrates stress response signaling governing fungal drug resistance.

Cowen LE. Cowen LE. PLoS Pathog. 2009 Aug;5(8):e1000471. doi: 10.1371/journal.ppat.1000471. Epub 2009 Aug 28. PLoS Pathog. 2009. PMID: 19714223 Free PMC article. No abstract available.

10

PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90.

LaFayette SL, Collins C, Zaas AK, Schell WA, Betancourt-Quiroz M, Gunatilaka AA, Perfect JR, Cowen LE. LaFayette SL, et al. Among authors: cowen le. PLoS Pathog. 2010 Aug 26;6(8):e1001069. doi: 10.1371/journal.ppat.1001069. PLoS Pathog. 2010. PMID: 20865172 Free PMC article.

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