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Vitamin D (1,25(OH)2D3) induces α-1-antitrypsin synthesis by CD4+ T cells, which is required for 1,25(OH)2D3-driven IL-10.
Dimeloe S, Rice LV, Chen H, Cheadle C, Raynes J, Pfeffer P, Lavender P, Richards DF, Nyon MP, McDonnell JM, Kemper C, Gooptu B, Hawrylowicz CM. Dimeloe S, et al. Among authors: pfeffer p. J Steroid Biochem Mol Biol. 2019 May;189:1-9. doi: 10.1016/j.jsbmb.2019.01.014. Epub 2019 Jan 25. J Steroid Biochem Mol Biol. 2019. PMID: 30690074 Free PMC article.
Vitamin D and lung disease.
Pfeffer PE, Hawrylowicz CM. Pfeffer PE, et al. Thorax. 2012 Nov;67(11):1018-20. doi: 10.1136/thoraxjnl-2012-202139. Epub 2012 Aug 30. Thorax. 2012. PMID: 22935474
Vitamin D enhances production of soluble ST2, inhibiting the action of IL-33.
Pfeffer PE, Chen YH, Woszczek G, Matthews NC, Chevretton E, Gupta A, Saglani S, Bush A, Corrigan C, Cousins DJ, Hawrylowicz CM. Pfeffer PE, et al. J Allergy Clin Immunol. 2015 Mar;135(3):824-7.e3. doi: 10.1016/j.jaci.2014.09.044. Epub 2014 Nov 12. J Allergy Clin Immunol. 2015. PMID: 25457999 Free PMC article. No abstract available.
Distinct endotypes of steroid-resistant asthma characterized by IL-17A(high) and IFN-γ(high) immunophenotypes: Potential benefits of calcitriol.
Chambers ES, Nanzer AM, Pfeffer PE, Richards DF, Timms PM, Martineau AR, Griffiths CJ, Corrigan CJ, Hawrylowicz CM. Chambers ES, et al. J Allergy Clin Immunol. 2015 Sep;136(3):628-637.e4. doi: 10.1016/j.jaci.2015.01.026. Epub 2015 Mar 13. J Allergy Clin Immunol. 2015. PMID: 25772594 Free PMC article. Clinical Trial.
313 results