Morales JC - Search Results

1

A Photoresponsive Stiff-Stilbene Ligand Fuels the Reversible Unfolding of G-Quadruplex DNA.

O'Hagan MP, Haldar S, Duchi M, Oliver TAA, Mulholland AJ, Morales JC, Galan MC. O'Hagan MP, et al. Among authors: morales jc. Angew Chem Int Ed Engl. 2019 Mar 22;58(13):4334-4338. doi: 10.1002/anie.201900740. Epub 2019 Feb 20. Angew Chem Int Ed Engl. 2019. PMID: 30682233 Free PMC article.

2

Divalent Naphthalene Diimide Ligands Display High Selectivity for the Human Telomeric G-quadruplex in K⁺ Buffer.

Street STG, Chin DN, Hollingworth GJ, Berry M, Morales JC, Galan MC. Street STG, et al. Among authors: morales jc. Chemistry. 2017 May 23;23(29):6953-6958. doi: 10.1002/chem.201700140. Epub 2017 Mar 30. Chemistry. 2017. PMID: 28257554 Free PMC article.

3

G-Quadruplex Identification in the Genome of Protozoan Parasites Points to Naphthalene Diimide Ligands as New Antiparasitic Agents.

Belmonte-Reche E, Martínez-García M, Guédin A, Zuffo M, Arévalo-Ruiz M, Doria F, Campos-Salinas J, Maynadier M, López-Rubio JJ, Freccero M, Mergny JL, Pérez-Victoria JM, Morales JC. Belmonte-Reche E, et al. Among authors: morales jc. J Med Chem. 2018 Feb 8;61(3):1231-1240. doi: 10.1021/acs.jmedchem.7b01672. Epub 2018 Jan 27. J Med Chem. 2018. PMID: 29323491 Free PMC article.

4

Stiff-Stilbene Ligands Target G-Quadruplex DNA and Exhibit Selective Anticancer and Antiparasitic Activity.

O'Hagan MP, Peñalver P, Gibson RSL, Morales JC, Galan MC. O'Hagan MP, et al. Among authors: morales jc. Chemistry. 2020 May 15;26(28):6224-6233. doi: 10.1002/chem.201905753. Epub 2020 Apr 28. Chemistry. 2020. PMID: 32030823 Free PMC article.

5

Symmetric and dissymmetric carbohydrate-phenyl ditriazole derivatives as DNA G-quadruplex ligands: Synthesis, biophysical studies and antiproliferative activity.

Arévalo-Ruiz M, Amrane S, Rosu F, Belmonte-Reche E, Peñalver P, Mergny JL, Morales JC. Arévalo-Ruiz M, et al. Among authors: morales jc. Bioorg Chem. 2020 Jun;99:103786. doi: 10.1016/j.bioorg.2020.103786. Epub 2020 Mar 21. Bioorg Chem. 2020. PMID: 32229349

6

Visible-light photoswitching of ligand binding mode suggests G-quadruplex DNA as a target for photopharmacology.

O'Hagan MP , Ramos-Soriano J , Haldar S , Sheikh S , Morales JC , Mulholland AJ , Galan MC . O'Hagan MP , et al. Among authors: morales jc. Chem Commun (Camb). 2020 May 11;56(38):5186-5189. doi: 10.1039/d0cc01581d. Epub 2020 Apr 8. Chem Commun (Camb). 2020. PMID: 32267261

7

Imide Condensation as a Strategy for the Synthesis of Core-Diversified G-Quadruplex Ligands with Anticancer and Antiparasitic Activity*.

Street STG, Peñalver P, O'Hagan MP, Hollingworth GJ, Morales JC, Galan MC. Street STG, et al. Among authors: morales jc. Chemistry. 2021 May 17;27(28):7712-7721. doi: 10.1002/chem.202100040. Epub 2021 May 2. Chemistry. 2021. PMID: 33780044 Free PMC article.

8

Enhanced sampling molecular dynamics simulations correctly predict the diverse activities of a series of stiff-stilbene G-quadruplex DNA ligands.

O'Hagan MP, Haldar S, Morales JC, Mulholland AJ, Galan MC. O'Hagan MP, et al. Among authors: morales jc. Chem Sci. 2020 Nov 26;12(4):1415-1426. doi: 10.1039/d0sc05223j. Chem Sci. 2020. PMID: 34163904 Free PMC article.

9

G-Quadruplex DNA as a Target in Pathogenic Bacteria: Efficacy of an Extended Naphthalene Diimide Ligand and Its Mode of Action.

Cebrián R, Belmonte-Reche E, Pirota V, de Jong A, Morales JC, Freccero M, Doria F, Kuipers OP. Cebrián R, et al. Among authors: morales jc. J Med Chem. 2022 Mar 24;65(6):4752-4766. doi: 10.1021/acs.jmedchem.1c01905. Epub 2021 Dec 20. J Med Chem. 2022. PMID: 34928608 Free PMC article.

10

Structure-activity relationship studies on divalent naphthalene diimide G quadruplex ligands with anticancer and antiparasitic activity.

Pérez-Soto M, Peñalver P, Street STG, Weenink D, O'Hagan MP, Ramos-Soriano J, Jiang YJ, Hollingworth GJ, Galan MC, Morales JC. Pérez-Soto M, et al. Among authors: morales jc. Bioorg Med Chem. 2022 Oct 1;71:116946. doi: 10.1016/j.bmc.2022.116946. Epub 2022 Jul 26. Bioorg Med Chem. 2022. PMID: 35939903 Free article.

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