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Dual-tail arylsulfone-based benzenesulfonamides differently match the hydrophobic and hydrophilic halves of human carbonic anhydrases active sites: Selective inhibitors for the tumor-associated hCA IX isoform.
Ibrahim HS, Allam HA, Mahmoud WR, Bonardi A, Nocentini A, Gratteri P, Ibrahim ES, Abdel-Aziz HA, Supuran CT. Ibrahim HS, et al. Among authors: allam ha. Eur J Med Chem. 2018 May 25;152:1-9. doi: 10.1016/j.ejmech.2018.04.016. Epub 2018 Apr 10. Eur J Med Chem. 2018. PMID: 29684705
Application of hydrazino and hydrazido linkers to connect benzenesulfonamides with hydrophilic/phobic tails for targeting the middle region of human carbonic anhydrases active site: Selective inhibitors of hCA IX.
Allam HA, Fahim SH, F Abo-Ashour M, Nocentini A, Elbakry ME, Abdelrahman MA, Eldehna WM, Ibrahim HS, Supuran CT. Allam HA, et al. Eur J Med Chem. 2019 Oct 1;179:547-556. doi: 10.1016/j.ejmech.2019.06.081. Epub 2019 Jun 28. Eur J Med Chem. 2019. PMID: 31276899
Effect of hydrophobic extension of aryl enaminones and pyrazole-linked compounds combined with sulphonamide, sulfaguanidine, or carboxylic acid functionalities on carbonic anhydrase inhibitory potency and selectivity.
Allam HA, Albakry ME, Mahmoud WR, Bonardi A, Moussa SA, Mohamady S, Abdel-Aziz HA, Supuran CT, Ibrahim HS. Allam HA, et al. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2201403. doi: 10.1080/14756366.2023.2201403. J Enzyme Inhib Med Chem. 2023. PMID: 37078174 Free PMC article.
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