Kong X - Search Results

1

Communication between the Ligand-Binding Pocket and the Activation Function-2 Domain of Androgen Receptor Revealed by Molecular Dynamics Simulations.

Jin Y, Duan M, Wang X, Kong X, Zhou W, Sun H, Liu H, Li D, Yu H, Li Y, Hou T. Jin Y, et al. Among authors: kong x. J Chem Inf Model. 2019 Feb 25;59(2):842-857. doi: 10.1021/acs.jcim.8b00796. Epub 2019 Feb 6. J Chem Inf Model. 2019. PMID: 30658039

2

Identification and Preliminary SAR Analysis of Novel Type-I Inhibitors of TIE-2 via Structure-Based Virtual Screening and Biological Evaluation in in vitro Models.

Pan P, Tian S, Sun H, Kong X, Zhou W, Li D, Li Y, Hou T. Pan P, et al. Among authors: kong x. J Chem Inf Model. 2015 Dec 28;55(12):2693-704. doi: 10.1021/acs.jcim.5b00576. Epub 2015 Dec 15. J Chem Inf Model. 2015. PMID: 26618892

3

Molecular principle of the cyclin-dependent kinase selectivity of 4-(thiazol-5-yl)-2-(phenylamino) pyrimidine-5-carbonitrile derivatives revealed by molecular modeling studies.

Kong X, Sun H, Pan P, Tian S, Li D, Li Y, Hou T. Kong X, et al. Phys Chem Chem Phys. 2016 Jan 21;18(3):2034-46. doi: 10.1039/c5cp05622e. Epub 2015 Dec 21. Phys Chem Chem Phys. 2016. PMID: 26686753

4

Importance of protein flexibility in ranking inhibitor affinities: modeling the binding mechanisms of piperidine carboxamides as Type I1/2 ALK inhibitors.

Kong X, Pan P, Li D, Tian S, Li Y, Hou T. Kong X, et al. Phys Chem Chem Phys. 2015 Feb 28;17(8):6098-113. doi: 10.1039/c4cp05440g. Phys Chem Chem Phys. 2015. PMID: 25644934

5

In Silico Exploration for Novel Type-I Inhibitors of Tie-2/TEK: The Performance of Different Selection Strategy in Selecting Virtual Screening Candidates.

Pan P, Sun H, Liu H, Li D, Zhou W, Kong X, Li Y, Yu H, Hou T. Pan P, et al. Among authors: kong x. Sci Rep. 2016 Nov 23;6:37628. doi: 10.1038/srep37628. Sci Rep. 2016. PMID: 27876862 Free PMC article.

6

How Does the L884P Mutation Confer Resistance to Type-II Inhibitors of JAK2 Kinase: A Comprehensive Molecular Modeling Study.

Kong X, Sun H, Pan P, Li D, Zhu F, Chang S, Xu L, Li Y, Hou T. Kong X, et al. Sci Rep. 2017 Aug 22;7(1):9088. doi: 10.1038/s41598-017-09586-3. Sci Rep. 2017. PMID: 28831147 Free PMC article.

7

Importance of protein flexibility in molecular recognition: a case study on Type-I1/2 inhibitors of ALK.

Kong X , Sun H , Pan P , Zhu F , Chang S , Xu L , Li Y , Hou T . Kong X , et al. Phys Chem Chem Phys. 2018 Feb 14;20(7):4851-4863. doi: 10.1039/c7cp08241j. Phys Chem Chem Phys. 2018. PMID: 29383359

8

Combating Drug-Resistant Mutants of Anaplastic Lymphoma Kinase with Potent and Selective Type-I^1/2 Inhibitors by Stabilizing Unique DFG-Shifted Loop Conformation.

Pan P, Yu H, Liu Q, Kong X, Chen H, Chen J, Liu Q, Li D, Kang Y, Sun H, Zhou W, Tian S, Cui S, Zhu F, Li Y, Huang Y, Hou T. Pan P, et al. Among authors: kong x. ACS Cent Sci. 2017 Nov 22;3(11):1208-1220. doi: 10.1021/acscentsci.7b00419. Epub 2017 Nov 3. ACS Cent Sci. 2017. PMID: 29202023 Free PMC article.

9

Drug Discovery Targeting Anaplastic Lymphoma Kinase (ALK).

Kong X, Pan P, Sun H, Xia H, Wang X, Li Y, Hou T. Kong X, et al. J Med Chem. 2019 Dec 26;62(24):10927-10954. doi: 10.1021/acs.jmedchem.9b00446. Epub 2019 Aug 26. J Med Chem. 2019. PMID: 31419130 Review.

10

Constructing and Validating High-Performance MIEC-SVM Models in Virtual Screening for Kinases: A Better Way for Actives Discovery.

Sun H, Pan P, Tian S, Xu L, Kong X, Li Y, Dan Li, Hou T. Sun H, et al. Among authors: kong x. Sci Rep. 2016 Apr 22;6:24817. doi: 10.1038/srep24817. Sci Rep. 2016. PMID: 27102549 Free PMC article.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

8,951 results

Search Page

Filters