El-Achkar TM - Search Results

1

Uromodulin (Tamm-Horsfall protein): guardian of urinary and systemic homeostasis.

Micanovic R, LaFavers K, Garimella PS, Wu XR, El-Achkar TM. Micanovic R, et al. Nephrol Dial Transplant. 2020 Jan 1;35(1):33-43. doi: 10.1093/ndt/gfy394. Nephrol Dial Transplant. 2020. PMID: 30649494 Free PMC article. Review.

2

Tamm-Horsfall protein protects the kidney from ischemic injury by decreasing inflammation and altering TLR4 expression.

El-Achkar TM, Wu XR, Rauchman M, McCracken R, Kiefer S, Dagher PC. El-Achkar TM, et al. Am J Physiol Renal Physiol. 2008 Aug;295(2):F534-44. doi: 10.1152/ajprenal.00083.2008. Epub 2008 May 21. Am J Physiol Renal Physiol. 2008. PMID: 18495803 Free PMC article.

3

Tamm-Horsfall protein-deficient thick ascending limbs promote injury to neighboring S3 segments in an MIP-2-dependent mechanism.

El-Achkar TM, McCracken R, Rauchman M, Heitmeier MR, Al-Aly Z, Dagher PC, Wu XR. El-Achkar TM, et al. Am J Physiol Renal Physiol. 2011 Apr;300(4):F999-1007. doi: 10.1152/ajprenal.00621.2010. Epub 2011 Jan 12. Am J Physiol Renal Physiol. 2011. PMID: 21228114 Free PMC article.

4

Molecular and cellular effects of Tamm-Horsfall protein mutations and their rescue by chemical chaperones.

Ma L, Liu Y, El-Achkar TM, Wu XR. Ma L, et al. J Biol Chem. 2012 Jan 6;287(2):1290-305. doi: 10.1074/jbc.M111.283036. Epub 2011 Nov 22. J Biol Chem. 2012. PMID: 22117067 Free PMC article.

5

Uromodulin in kidney injury: an instigator, bystander, or protector?

El-Achkar TM, Wu XR. El-Achkar TM, et al. Am J Kidney Dis. 2012 Mar;59(3):452-61. doi: 10.1053/j.ajkd.2011.10.054. Epub 2012 Jan 23. Am J Kidney Dis. 2012. PMID: 22277744 Free PMC article. Review.

6

Tamm-Horsfall protein regulates circulating and renal cytokines by affecting glomerular filtration rate and acting as a urinary cytokine trap.

Liu Y, El-Achkar TM, Wu XR. Liu Y, et al. J Biol Chem. 2012 May 11;287(20):16365-78. doi: 10.1074/jbc.M112.348243. Epub 2012 Mar 27. J Biol Chem. 2012. PMID: 22451664 Free PMC article.

7

Tamm-Horsfall protein translocates to the basolateral domain of thick ascending limbs, interstitium, and circulation during recovery from acute kidney injury.

El-Achkar TM, McCracken R, Liu Y, Heitmeier MR, Bourgeois S, Ryerse J, Wu XR. El-Achkar TM, et al. Am J Physiol Renal Physiol. 2013 Apr 15;304(8):F1066-75. doi: 10.1152/ajprenal.00543.2012. Epub 2013 Feb 6. Am J Physiol Renal Physiol. 2013. PMID: 23389456 Free PMC article.

8

An intricate network of conserved DNA upstream motifs and associated transcription factors regulate the expression of uromodulin gene.

Srivastava R, Micanovic R, El-Achkar TM, Janga SC. Srivastava R, et al. J Urol. 2014 Sep;192(3):981-9. doi: 10.1016/j.juro.2014.02.095. Epub 2014 Mar 1. J Urol. 2014. PMID: 24594405

9

The role of tumor necrosis factor alpha in regulating the expression of Tamm-Horsfall Protein (uromodulin) in thick ascending limbs during kidney injury.

Heitmeier M, McCracken R, Micanovic R, Khan S, El-Achkar TM. Heitmeier M, et al. Am J Nephrol. 2014;40(5):458-67. doi: 10.1159/000369836. Epub 2014 Dec 6. Am J Nephrol. 2014. PMID: 25503683 Free PMC article.

10

Tamm-Horsfall Protein Regulates Granulopoiesis and Systemic Neutrophil Homeostasis.

Micanovic R, Chitteti BR, Dagher PC, Srour EF, Khan S, Hato T, Lyle A, Tong Y, Wu XR, El-Achkar TM. Micanovic R, et al. J Am Soc Nephrol. 2015 Sep;26(9):2172-82. doi: 10.1681/ASN.2014070664. Epub 2015 Jan 2. J Am Soc Nephrol. 2015. PMID: 25556169 Free PMC article.

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