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Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration.
Melamed Z, López-Erauskin J, Baughn MW, Zhang O, Drenner K, Sun Y, Freyermuth F, McMahon MA, Beccari MS, Artates JW, Ohkubo T, Rodriguez M, Lin N, Wu D, Bennett CF, Rigo F, Da Cruz S, Ravits J, Lagier-Tourenne C, Cleveland DW. Melamed Z, et al. Among authors: ohkubo t. Nat Neurosci. 2019 Feb;22(2):180-190. doi: 10.1038/s41593-018-0293-z. Epub 2019 Jan 14. Nat Neurosci. 2019. PMID: 30643298 Free PMC article.
Sense-encoded poly-GR dipeptide repeat proteins correlate to neurodegeneration and uniquely co-localize with TDP-43 in dendrites of repeat-expanded C9orf72 amyotrophic lateral sclerosis.
Saberi S, Stauffer JE, Jiang J, Garcia SD, Taylor AE, Schulte D, Ohkubo T, Schloffman CL, Maldonado M, Baughn M, Rodriguez MJ, Pizzo D, Cleveland D, Ravits J. Saberi S, et al. Among authors: ohkubo t. Acta Neuropathol. 2018 Mar;135(3):459-474. doi: 10.1007/s00401-017-1793-8. Epub 2017 Dec 1. Acta Neuropathol. 2018. PMID: 29196813 Free PMC article.
Antisense RNA foci are associated with nucleoli and TDP-43 mislocalization in C9orf72-ALS/FTD: a quantitative study.
Aladesuyi Arogundade O, Stauffer JE, Saberi S, Diaz-Garcia S, Malik S, Basilim H, Rodriguez MJ, Ohkubo T, Ravits J. Aladesuyi Arogundade O, et al. Among authors: ohkubo t. Acta Neuropathol. 2019 Mar;137(3):527-530. doi: 10.1007/s00401-018-01955-0. Epub 2019 Jan 21. Acta Neuropathol. 2019. PMID: 30666413 Free PMC article. No abstract available.
Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS.
Miller TM, Cudkowicz ME, Genge A, Shaw PJ, Sobue G, Bucelli RC, Chiò A, Van Damme P, Ludolph AC, Glass JD, Andrews JA, Babu S, Benatar M, McDermott CJ, Cochrane T, Chary S, Chew S, Zhu H, Wu F, Nestorov I, Graham D, Sun P, McNeill M, Fanning L, Ferguson TA, Fradette S; VALOR and OLE Working Group. Miller TM, et al. N Engl J Med. 2022 Sep 22;387(12):1099-1110. doi: 10.1056/NEJMoa2204705. N Engl J Med. 2022. PMID: 36129998 Free article. Clinical Trial.
Implementing Motor Unit Number Index (MUNIX) in a large clinical trial: Real world experience from 27 centres.
Neuwirth C, Braun N, Claeys KG, Bucelli R, Fournier C, Bromberg M, Petri S, Goedee S, Lenglet T, Leppanen R, Canosa A, Goodman I, Al-Lozi M, Ohkubo T, Hübers A, Atassi N, Abrahao A, Funke A, Appelfeller M, Tümmler A, Finegan E, Glass JD, Babu S, Ladha SS, Kwast-Rabben O, Juntas-Morales R, Coffey A, Chaudhry V, Vu T, Saephanh C, Newhard C, Zakrzewski M, Rosier E, Hamel N, Raheja D, Raaijman J, Ferguson T, Weber M. Neuwirth C, et al. Among authors: ohkubo t. Clin Neurophysiol. 2018 Aug;129(8):1756-1762. doi: 10.1016/j.clinph.2018.04.614. Epub 2018 May 3. Clin Neurophysiol. 2018. PMID: 29803404 Clinical Trial.
Enhanced Hypercoagulability Using Clot Waveform Analysis in Patients with Acute Myocardial Infarction and Acute Cerebral Infarction.
Masuda J, Wada H, Kato T, Tanigaito Y, Hayashi K, Yamada K, Nishida K, Oizumi H, Kamon T, Ohkubo T, Okamoto K, Ito N, Shiraki K, Ichikawa Y, Shimaoka M, Dohi K, Shimpo H. Masuda J, et al. Among authors: ohkubo t. J Clin Med. 2024 Nov 26;13(23):7181. doi: 10.3390/jcm13237181. J Clin Med. 2024. PMID: 39685640 Free PMC article.
The Thermal-Stable LH1-RC Complex of a Hot Spring Purple Bacterium Powers Photosynthesis with Extremely Low-Energy Near-Infrared Light.
Kimura Y, Kanno R, Mori K, Matsuda Y, Seto R, Takenaka S, Mino H, Ohkubo T, Honda M, Sasaki YC, Kishikawa JI, Mitsuoka K, Mio K, Hall M, Purba ER, Mochizuki T, Mizoguchi A, Humbel BM, Madigan MT, Wang-Otomo ZY, Tani K. Kimura Y, et al. Among authors: ohkubo t. Biochemistry. 2025 Jan 7;64(1):170-179. doi: 10.1021/acs.biochem.4c00506. Epub 2024 Dec 16. Biochemistry. 2025. PMID: 39680849
1,600 results