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Cancer: A metabolic metamorphosis.
Krall AS, Christofk HR. Krall AS, et al. Among authors: christofk hr. Nature. 2013 Apr 4;496(7443):38-40. doi: 10.1038/496038a. Nature. 2013. PMID: 23552939 No abstract available.
The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR.
Chin RM, Fu X, Pai MY, Vergnes L, Hwang H, Deng G, Diep S, Lomenick B, Meli VS, Monsalve GC, Hu E, Whelan SA, Wang JX, Jung G, Solis GM, Fazlollahi F, Kaweeteerawat C, Quach A, Nili M, Krall AS, Godwin HA, Chang HR, Faull KF, Guo F, Jiang M, Trauger SA, Saghatelian A, Braas D, Christofk HR, Clarke CF, Teitell MA, Petrascheck M, Reue K, Jung ME, Frand AR, Huang J. Chin RM, et al. Among authors: christofk hr. Nature. 2014 Jun 19;510(7505):397-401. doi: 10.1038/nature13264. Epub 2014 May 14. Nature. 2014. PMID: 24828042 Free PMC article.
Autocrine VEGF maintains endothelial survival through regulation of metabolism and autophagy.
Domigan CK, Warren CM, Antanesian V, Happel K, Ziyad S, Lee S, Krall A, Duan L, Torres-Collado AX, Castellani LW, Elashoff D, Christofk HR, van der Bliek AM, Potente M, Iruela-Arispe ML. Domigan CK, et al. Among authors: christofk hr. J Cell Sci. 2015 Jun 15;128(12):2236-48. doi: 10.1242/jcs.163774. Epub 2015 May 8. J Cell Sci. 2015. PMID: 25956888 Free PMC article.
Rethinking glutamine addiction.
Krall AS, Christofk HR. Krall AS, et al. Among authors: christofk hr. Nat Cell Biol. 2015 Dec;17(12):1515-7. doi: 10.1038/ncb3278. Nat Cell Biol. 2015. PMID: 26612572
MCT1 Modulates Cancer Cell Pyruvate Export and Growth of Tumors that Co-express MCT1 and MCT4.
Hong CS, Graham NA, Gu W, Espindola Camacho C, Mah V, Maresh EL, Alavi M, Bagryanova L, Krotee PAL, Gardner BK, Behbahan IS, Horvath S, Chia D, Mellinghoff IK, Hurvitz SA, Dubinett SM, Critchlow SE, Kurdistani SK, Goodglick L, Braas D, Graeber TG, Christofk HR. Hong CS, et al. Among authors: christofk hr. Cell Rep. 2016 Feb 23;14(7):1590-1601. doi: 10.1016/j.celrep.2016.01.057. Epub 2016 Feb 11. Cell Rep. 2016. PMID: 26876179 Free PMC article.
83 results