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Safety, tolerability, pharmacokinetics and effect on serum uric acid of the myeloperoxidase inhibitor AZD4831 in a randomized, placebo-controlled, phase I study in healthy volunteers.
Gan LM, Lagerström-Fermér M, Ericsson H, Nelander K, Lindstedt EL, Michaëlsson E, Kjaer M, Heijer M, Whatling C, Fuhr R. Gan LM, et al. Among authors: michaelsson e. Br J Clin Pharmacol. 2019 Apr;85(4):762-770. doi: 10.1111/bcp.13855. Epub 2019 Feb 18. Br J Clin Pharmacol. 2019. PMID: 30618054 Free PMC article. Clinical Trial.
Myeloperoxidase is a potential molecular imaging and therapeutic target for the identification and stabilization of high-risk atherosclerotic plaque.
Rashid I, Maghzal GJ, Chen YC, Cheng D, Talib J, Newington D, Ren M, Vajandar SK, Searle A, Maluenda A, Lindstedt EL, Jabbour A, Kettle AJ, Bongers A, Power C, Michaëlsson E, Peter K, Stocker R. Rashid I, et al. Among authors: michaelsson e. Eur Heart J. 2018 Sep 14;39(35):3301-3310. doi: 10.1093/eurheartj/ehy419. Eur Heart J. 2018. PMID: 30219874
Inhibition of MPO (Myeloperoxidase) Attenuates Endothelial Dysfunction in Mouse Models of Vascular Inflammation and Atherosclerosis.
Cheng D, Talib J, Stanley CP, Rashid I, Michaëlsson E, Lindstedt EL, Croft KD, Kettle AJ, Maghzal GJ, Stocker R. Cheng D, et al. Among authors: michaelsson e. Arterioscler Thromb Vasc Biol. 2019 Jul;39(7):1448-1457. doi: 10.1161/ATVBAHA.119.312725. Epub 2019 May 2. Arterioscler Thromb Vasc Biol. 2019. PMID: 31043077 Free article.
Stimulation of alpha 7 nicotinic acetylcholine receptor (α7nAChR) inhibits atherosclerosis via immunomodulatory effects on myeloid cells.
Ulleryd MA, Mjörnstedt F, Panagaki D, Yang LJ, Engevall K, Gutiérrez S, Wang Y, Gan LM, Nilsson H, Michaëlsson E, Johansson ME. Ulleryd MA, et al. Among authors: michaelsson e. Atherosclerosis. 2019 Aug;287:122-133. doi: 10.1016/j.atherosclerosis.2019.06.903. Epub 2019 Jun 15. Atherosclerosis. 2019. PMID: 31260875
RNA sequencing data describing transcriptional changes in aorta of ApoE-/- mice after alpha 7 nicotinic acetylcholine receptor (α7nAChR) stimulation.
Ulleryd MA, Mjörnstedt F, Panagaki D, Yang LJ, Engevall K, Gutierrez S, Wang Y, Gan LM, Nilsson H, Michaëlsson E, Johansson ME. Ulleryd MA, et al. Among authors: michaelsson e. Data Brief. 2020 Mar 12;30:105415. doi: 10.1016/j.dib.2020.105415. eCollection 2020 Jun. Data Brief. 2020. PMID: 32258279 Free PMC article.
62 results