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Safety, tolerability, pharmacokinetics and effect on serum uric acid of the myeloperoxidase inhibitor AZD4831 in a randomized, placebo-controlled, phase I study in healthy volunteers.
Gan LM, Lagerström-Fermér M, Ericsson H, Nelander K, Lindstedt EL, Michaëlsson E, Kjaer M, Heijer M, Whatling C, Fuhr R. Gan LM, et al. Br J Clin Pharmacol. 2019 Apr;85(4):762-770. doi: 10.1111/bcp.13855. Epub 2019 Feb 18. Br J Clin Pharmacol. 2019. PMID: 30618054 Free PMC article. Clinical Trial.
Intradermal delivery of modified mRNA encoding VEGF-A in patients with type 2 diabetes.
Gan LM, Lagerström-Fermér M, Carlsson LG, Arfvidsson C, Egnell AC, Rudvik A, Kjaer M, Collén A, Thompson JD, Joyal J, Chialda L, Koernicke T, Fuhr R, Chien KR, Fritsche-Danielson R. Gan LM, et al. Nat Commun. 2019 Feb 20;10(1):871. doi: 10.1038/s41467-019-08852-4. Nat Commun. 2019. PMID: 30787295 Free PMC article.
Biomarker Correlates of Coronary Microvascular Dysfunction in Heart Failure With Preserved Ejection Fraction.
Tromp J, Hage C, Ouwerkerk W, Sanders-van Wijk S, Svedlund S, Saraste A, Ljung Faxén U, Lagerstrom Fermer M, Gan LM, Lund LH, Shah SJ, Lam CSP. Tromp J, et al. Among authors: lagerstrom fermer m. Circulation. 2019 Oct 15;140(16):1359-1361. doi: 10.1161/CIRCULATIONAHA.119.042569. Epub 2019 Oct 14. Circulation. 2019. PMID: 31609659 Free PMC article. No abstract available.
PROspective evaluation of coronary FLOW reserve and molecular biomarkers in patients with established coronary artery disease the PROFLOW-trial: cross-sectional evaluation of coronary flow reserve.
Haraldsson I, Gan LM, Svedlund S, Torngren K, Westergren HU, Redfors B, Lagerström-Fermér M, Angerås O, Råmunddal T, Petursson P, Odenstedt J, Albertsson P, Erlinge D, Omerovic E. Haraldsson I, et al. Among authors: lagerstrom fermer m. Vasc Health Risk Manag. 2019 Aug 28;15:375-384. doi: 10.2147/VHRM.S209003. eCollection 2019. Vasc Health Risk Manag. 2019. PMID: 31695398 Free PMC article.
Phase 1 Pharmacokinetic Study of AZD5718 in Healthy Volunteers: Effects of Coadministration With Rosuvastatin, Formulation and Food on Oral Bioavailability.
Ericsson H, Nelander K, Heijer M, Kjaer M, Lindstedt EL, Albayaty M, Forte P, Lagerström-Fermér M, Skrtic S. Ericsson H, et al. Among authors: lagerstrom fermer m. Clin Pharmacol Drug Dev. 2020 Apr;9(3):411-421. doi: 10.1002/cpdd.756. Epub 2019 Dec 2. Clin Pharmacol Drug Dev. 2020. PMID: 31793171 Free PMC article. Clinical Trial.
Synthetic mRNA Encoding VEGF-A in Patients Undergoing Coronary Artery Bypass Grafting: Design of a Phase 2a Clinical Trial.
Anttila V, Saraste A, Knuuti J, Jaakkola P, Hedman M, Svedlund S, Lagerström-Fermér M, Kjaer M, Jeppsson A, Gan LM. Anttila V, et al. Among authors: lagerstrom fermer m. Mol Ther Methods Clin Dev. 2020 Jun 1;18:464-472. doi: 10.1016/j.omtm.2020.05.030. eCollection 2020 Sep 11. Mol Ther Methods Clin Dev. 2020. PMID: 32728595 Free PMC article.
Early Clinical Experience With AZD4831, A Novel Myeloperoxidase Inhibitor, Developed for Patients With Heart Failure With Preserved Ejection Fraction.
Nelander K, Lagerstrom-Fermer M, Amilon C, Michaëlsson E, Heijer M, Kjaer M, Russell M, Han D, Lindstedt EL, Whatling C, Gan LM, Ericsson H. Nelander K, et al. Among authors: lagerstrom fermer m. Clin Transl Sci. 2021 May;14(3):812-819. doi: 10.1111/cts.12859. Epub 2021 May 2. Clin Transl Sci. 2021. PMID: 32770730 Free PMC article. Clinical Trial.
Design and rationale of FLAVOUR: A phase IIa efficacy study of the 5-lipoxygenase activating protein antagonist AZD5718 in patients with recent myocardial infarction.
Prescott E, Pernow J, Saraste A, Åkerblom A, Angerås O, Erlinge D, Grove EL, Hedman M, Jensen LO, Svedlund S, Kjaer M, Lagerström-Fermér M, Gan LM. Prescott E, et al. Among authors: lagerstrom fermer m. Contemp Clin Trials Commun. 2020 Jul 30;19:100629. doi: 10.1016/j.conctc.2020.100629. eCollection 2020 Sep. Contemp Clin Trials Commun. 2020. PMID: 32875138 Free PMC article.
Generalizability of HFA-PEFF and H2FPEF Diagnostic Algorithms and Associations With Heart Failure Indices and Proteomic Biomarkers: Insights From PROMIS-HFpEF.
Faxen UL, Venkateshvaran A, Shah SJ, Lam CSP, Svedlund S, Saraste A, Beussink-Nelson L, Lagerstrom Fermer M, Gan LM, Hage C, Lund LH. Faxen UL, et al. Among authors: lagerstrom fermer m. J Card Fail. 2021 Jul;27(7):756-765. doi: 10.1016/j.cardfail.2021.02.005. Epub 2021 Feb 26. J Card Fail. 2021. PMID: 33647474 Free article.
30 results