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Page 1
Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models.
Lourenco MV, Frozza RL, de Freitas GB, Zhang H, Kincheski GC, Ribeiro FC, Gonçalves RA, Clarke JR, Beckman D, Staniszewski A, Berman H, Guerra LA, Forny-Germano L, Meier S, Wilcock DM, de Souza JM, Alves-Leon S, Prado VF, Prado MAM, Abisambra JF, Tovar-Moll F, Mattos P, Arancio O, Ferreira ST, De Felice FG. Lourenco MV, et al. Among authors: clarke jr. Nat Med. 2019 Jan;25(1):165-175. doi: 10.1038/s41591-018-0275-4. Epub 2019 Jan 7. Nat Med. 2019. PMID: 30617325 Free PMC article.
Amyloid-β oligomers link depressive-like behavior and cognitive deficits in mice.
Ledo JH, Azevedo EP, Clarke JR, Ribeiro FC, Figueiredo CP, Foguel D, De Felice FG, Ferreira ST. Ledo JH, et al. Among authors: clarke jr. Mol Psychiatry. 2013 Oct;18(10):1053-4. doi: 10.1038/mp.2012.168. Epub 2012 Nov 27. Mol Psychiatry. 2013. PMID: 23183490 Free PMC article. No abstract available.
Memantine rescues transient cognitive impairment caused by high-molecular-weight aβ oligomers but not the persistent impairment induced by low-molecular-weight oligomers.
Figueiredo CP, Clarke JR, Ledo JH, Ribeiro FC, Costa CV, Melo HM, Mota-Sales AP, Saraiva LM, Klein WL, Sebollela A, De Felice FG, Ferreira ST. Figueiredo CP, et al. Among authors: clarke jr. J Neurosci. 2013 Jun 5;33(23):9626-34. doi: 10.1523/JNEUROSCI.0482-13.2013. J Neurosci. 2013. PMID: 23739959 Free PMC article.
TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-amyloid oligomers in mice and monkeys.
Lourenco MV, Clarke JR, Frozza RL, Bomfim TR, Forny-Germano L, Batista AF, Sathler LB, Brito-Moreira J, Amaral OB, Silva CA, Freitas-Correa L, Espírito-Santo S, Campello-Costa P, Houzel JC, Klein WL, Holscher C, Carvalheira JB, Silva AM, Velloso LA, Munoz DP, Ferreira ST, De Felice FG. Lourenco MV, et al. Among authors: clarke jr. Cell Metab. 2013 Dec 3;18(6):831-43. doi: 10.1016/j.cmet.2013.11.002. Cell Metab. 2013. PMID: 24315369 Free article.
Alzheimer-associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation.
Clarke JR, Lyra E Silva NM, Figueiredo CP, Frozza RL, Ledo JH, Beckman D, Katashima CK, Razolli D, Carvalho BM, Frazão R, Silveira MA, Ribeiro FC, Bomfim TR, Neves FS, Klein WL, Medeiros R, LaFerla FM, Carvalheira JB, Saad MJ, Munoz DP, Velloso LA, Ferreira ST, De Felice FG. Clarke JR, et al. EMBO Mol Med. 2015 Feb;7(2):190-210. doi: 10.15252/emmm.201404183. EMBO Mol Med. 2015. PMID: 25617315 Free PMC article.
Brain-Defective Insulin Signaling Is Associated to Late Cognitive Impairment in Post-Septic Mice.
Neves FS, Marques PT, Barros-Aragão F, Nunes JB, Venancio AM, Cozachenco D, Frozza RL, Passos GF, Costa R, de Oliveira J, Engel DF, De Bem AF, Benjamim CF, De Felice FG, Ferreira ST, Clarke JR, Figueiredo CP. Neves FS, et al. Among authors: clarke jr. Mol Neurobiol. 2018 Jan;55(1):435-444. doi: 10.1007/s12035-016-0307-3. Epub 2016 Dec 13. Mol Neurobiol. 2018. PMID: 27966074
Interaction of amyloid-β (Aβ) oligomers with neurexin 2α and neuroligin 1 mediates synapse damage and memory loss in mice.
Brito-Moreira J, Lourenco MV, Oliveira MM, Ribeiro FC, Ledo JH, Diniz LP, Vital JFS, Magdesian MH, Melo HM, Barros-Aragão F, de Souza JM, Alves-Leon SV, Gomes FCA, Clarke JR, Figueiredo CP, De Felice FG, Ferreira ST. Brito-Moreira J, et al. Among authors: clarke jr. J Biol Chem. 2017 May 5;292(18):7327-7337. doi: 10.1074/jbc.M116.761189. Epub 2017 Mar 10. J Biol Chem. 2017. PMID: 28283575 Free PMC article.
Chronic sleep restriction promotes brain inflammation and synapse loss, and potentiates memory impairment induced by amyloid-β oligomers in mice.
Kincheski GC, Valentim IS, Clarke JR, Cozachenco D, Castelo-Branco MTL, Ramos-Lobo AM, Rumjanek VMBD, Donato J Jr, De Felice FG, Ferreira ST. Kincheski GC, et al. Among authors: clarke jr. Brain Behav Immun. 2017 Aug;64:140-151. doi: 10.1016/j.bbi.2017.04.007. Epub 2017 Apr 13. Brain Behav Immun. 2017. PMID: 28412140
Brain infusion of α-synuclein oligomers induces motor and non-motor Parkinson's disease-like symptoms in mice.
Fortuna JTS, Gralle M, Beckman D, Neves FS, Diniz LP, Frost PS, Barros-Aragão F, Santos LE, Gonçalves RA, Romão L, Zamberlan DC, Soares FAA, Braga C, Foguel D, Gomes FCA, De Felice FG, Ferreira ST, Clarke JR, Figueiredo CP. Fortuna JTS, et al. Among authors: clarke jr. Behav Brain Res. 2017 Aug 30;333:150-160. doi: 10.1016/j.bbr.2017.06.047. Epub 2017 Jun 29. Behav Brain Res. 2017. PMID: 28668282
336 results