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Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity.
Fell JB, Fischer JP, Baer BR, Ballard J, Blake JF, Bouhana K, Brandhuber BJ, Briere DM, Burgess LE, Burkard MR, Chiang H, Chicarelli MJ, Davidson K, Gaudino JJ, Hallin J, Hanson L, Hee K, Hicken EJ, Hinklin RJ, Marx MA, Mejia MJ, Olson P, Savechenkov P, Sudhakar N, Tang TP, Vigers GP, Zecca H, Christensen JG. Fell JB, et al. Among authors: chiang h. ACS Med Chem Lett. 2018 Nov 7;9(12):1230-1234. doi: 10.1021/acsmedchemlett.8b00382. eCollection 2018 Dec 13. ACS Med Chem Lett. 2018. PMID: 30613331 Free PMC article.
Identification of the Clinical Development Candidate MRTX849, a Covalent KRASG12C Inhibitor for the Treatment of Cancer.
Fell JB, Fischer JP, Baer BR, Blake JF, Bouhana K, Briere DM, Brown KD, Burgess LE, Burns AC, Burkard MR, Chiang H, Chicarelli MJ, Cook AW, Gaudino JJ, Hallin J, Hanson L, Hartley DP, Hicken EJ, Hingorani GP, Hinklin RJ, Mejia MJ, Olson P, Otten JN, Rhodes SP, Rodriguez ME, Savechenkov P, Smith DJ, Sudhakar N, Sullivan FX, Tang TP, Vigers GP, Wollenberg L, Christensen JG, Marx MA. Fell JB, et al. Among authors: chiang h. J Med Chem. 2020 Jul 9;63(13):6679-6693. doi: 10.1021/acs.jmedchem.9b02052. Epub 2020 Apr 6. J Med Chem. 2020. PMID: 32250617 Free article.
The class I/IV HDAC inhibitor mocetinostat increases tumor antigen presentation, decreases immune suppressive cell types and augments checkpoint inhibitor therapy.
Briere D, Sudhakar N, Woods DM, Hallin J, Engstrom LD, Aranda R, Chiang H, Sodré AL, Olson P, Weber JS, Christensen JG. Briere D, et al. Among authors: chiang h. Cancer Immunol Immunother. 2018 Mar;67(3):381-392. doi: 10.1007/s00262-017-2091-y. Epub 2017 Nov 9. Cancer Immunol Immunother. 2018. PMID: 29124315 Free PMC article.
Glesatinib Exhibits Antitumor Activity in Lung Cancer Models and Patients Harboring MET Exon 14 Mutations and Overcomes Mutation-mediated Resistance to Type I MET Inhibitors in Nonclinical Models.
Engstrom LD, Aranda R, Lee M, Tovar EA, Essenburg CJ, Madaj Z, Chiang H, Briere D, Hallin J, Lopez-Casas PP, Baños N, Menendez C, Hidalgo M, Tassell V, Chao R, Chudova DI, Lanman RB, Olson P, Bazhenova L, Patel SP, Graveel C, Nishino M, Shapiro GI, Peled N, Awad MM, Jänne PA, Christensen JG. Engstrom LD, et al. Among authors: chiang h. Clin Cancer Res. 2017 Nov 1;23(21):6661-6672. doi: 10.1158/1078-0432.CCR-17-1192. Epub 2017 Aug 1. Clin Cancer Res. 2017. PMID: 28765324 Clinical Trial.
First Constraints on the Epoch of Reionization Using the Non-Gaussianity of the Kinematic Sunyaev-Zel'dovich Effect from the South Pole Telescope and Herschel-SPIRE Observations.
Raghunathan S, Ade PAR, Anderson AJ, Ansarinejad B, Archipley M, Austermann JE, Balkenhol L, Beall JA, Benabed K, Bender AN, Benson BA, Bianchini F, Bleem LE, Bock J, Bouchet FR, Bryant L, Camphuis E, Carlstrom JE, Cecil TW, Chang CL, Chaubal P, Chiang HC, Chichura PM, Chou TL, Citron R, Coerver A, Crawford TM, Crites AT, Cukierman A, Daley C, Dibert KR, Dobbs MA, Doussot A, Dutcher D, Everett W, Feng C, Ferguson KR, Fichman K, Foster A, Galli S, Gallicchio J, Gambrel AE, Gardner RW, Ge F, George EM, Goeckner-Wald N, Gualtieri R, Guidi F, Guns S, Gupta N, de Haan T, Halverson NW, Hivon E, Holder GP, Holzapfel WL, Hood JC, Hrubes JD, Hryciuk A, Huang N, Hubmayr J, Irwin KD, Kéruzoré F, Khalife AR, Knox L, Korman M, Kornoelje K, Kuo CL, Lee AT, Levy K, Li D, Lowitz AE, Lu C, Maniyar A, Martsen ES, McMahon JJ, Menanteau F, Millea M, Montgomery J, Corbett Moran C, Nakato Y, Natoli T, Nibarger JP, Noble GI, Novosad V, Omori Y, Padin S, Pan Z, Paschos P, Patil S, Phadke KA, Prabhu K, Pryke C, Quan W, Rahimi M, Rahlin A, Reichardt CL, Rouble M, Ruhl JE, Saliwanchik BR, Schaffer KK, Schiappucci E, Sievers C, Smecher G, Sobrin JA, Stark AA, Stephen J, Suzuki A, Tandoi C, Thompson KL… See abstract for full author list ➔ Raghunathan S, et al. Among authors: chiang hc. Phys Rev Lett. 2024 Sep 20;133(12):121004. doi: 10.1103/PhysRevLett.133.121004. Phys Rev Lett. 2024. PMID: 39373410
Links between climatic histories and the rise and fall of a Pacific chiefdom.
Shen CC, Beardsley F, Gong SY, Kataoka O, Yoneda M, Yokoyama Y, Hu HM, Huang CY, Liu SC, Chiang HW, Wei HL, Chung YC, Jiang L, Lin AY, Fox J, David M, Lebehn J, Barnabas J, Kohler G, Richards ZT, Hobbs JA, McCoy MD. Shen CC, et al. Among authors: chiang hw. PNAS Nexus. 2024 Oct 1;3(10):pgae399. doi: 10.1093/pnasnexus/pgae399. eCollection 2024 Oct. PNAS Nexus. 2024. PMID: 39359402 Free PMC article.
2,150 results