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Epigenetically upregulated oncoprotein PLCE1 drives esophageal carcinoma angiogenesis and proliferation via activating the PI-PLCε-NF-κB signaling pathway and VEGF-C/ Bcl-2 expression.
Chen Y, Wang D, Peng H, Chen X, Han X, Yu J, Wang W, Liang L, Liu Z, Zheng Y, Hu J, Yang L, Li J, Zhou H, Cui X, Li F. Chen Y, et al. Among authors: liu z. Mol Cancer. 2019 Jan 4;18(1):1. doi: 10.1186/s12943-018-0930-x. Mol Cancer. 2019. PMID: 30609930 Free PMC article.
Hypomethylation-Linked Activation of PLCE1 Impedes Autophagy and Promotes Tumorigenesis through MDM2-Mediated Ubiquitination and Destabilization of p53.
Chen Y, Xin H, Peng H, Shi Q, Li M, Yu J, Tian Y, Han X, Chen X, Zheng Y, Li J, Yang Z, Yang L, Hu J, Huang X, Liu Z, Huang X, Zhou H, Cui X, Li F. Chen Y, et al. Among authors: liu z. Cancer Res. 2020 Jun 1;80(11):2175-2189. doi: 10.1158/0008-5472.CAN-19-1912. Epub 2020 Feb 17. Cancer Res. 2020. PMID: 32066565
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