Involvement of heat shock protein 90 in the degradation of mutant insulin receptors by the proteasome.
Imamura T, Haruta T, Takata Y, Usui I, Iwata M, Ishihara H, Ishiki M, Ishibashi O, Ueno E, Sasaoka T, Kobayashi M.
Imamura T, et al. Among authors: sasaoka t.
J Biol Chem. 1998 May 1;273(18):11183-8. doi: 10.1074/jbc.273.18.11183.
J Biol Chem. 1998.
PMID: 9556607
Free article.
The extreme insulin resistance of these patients was found to be caused by the decreased number of insulin receptors on the cell surface, due to the intracellular rapid degradation (Imamura, T., Takata, Y., Sasaoka, T., Takada, Y., Morioka, H., Haruta, T …
The extreme insulin resistance of these patients was found to be caused by the decreased number of insulin receptors on the cell surface, du …