Chen T - Search Results

1

CDK8 as a therapeutic target for cancers and recent developments in discovery of CDK8 inhibitors.

Xi M, Chen T, Wu C, Gao X, Wu Y, Luo X, Du K, Yu L, Cai T, Shen R, Sun H. Xi M, et al. Among authors: chen t. Eur J Med Chem. 2019 Feb 15;164:77-91. doi: 10.1016/j.ejmech.2018.11.076. Epub 2018 Dec 21. Eur J Med Chem. 2019. PMID: 30594029 Review.

2

Dual GSK-3β/AChE Inhibitors as a New Strategy for Multitargeting Anti-Alzheimer's Disease Drug Discovery.

Jiang XY, Chen TK, Zhou JT, He SY, Yang HY, Chen Y, Qu W, Feng F, Sun HP. Jiang XY, et al. ACS Med Chem Lett. 2018 Feb 9;9(3):171-176. doi: 10.1021/acsmedchemlett.7b00463. eCollection 2018 Mar 8. ACS Med Chem Lett. 2018. PMID: 29541355 Free PMC article.

3

Peptide-based and small synthetic molecule inhibitors on PD-1/PD-L1 pathway: A new choice for immunotherapy?

Chen T, Li Q, Liu Z, Chen Y, Feng F, Sun H. Chen T, et al. Among authors: chen y. Eur J Med Chem. 2019 Jan 1;161:378-398. doi: 10.1016/j.ejmech.2018.10.044. Epub 2018 Oct 19. Eur J Med Chem. 2019. PMID: 30384043 Review.

4

Small molecule modulators targeting protein kinase CK1 and CK2.

Qiao Y, Chen T, Yang H, Chen Y, Lin H, Qu W, Feng F, Liu W, Guo Q, Liu Z, Sun H. Qiao Y, et al. Among authors: chen t, chen y. Eur J Med Chem. 2019 Nov 1;181:111581. doi: 10.1016/j.ejmech.2019.111581. Epub 2019 Aug 1. Eur J Med Chem. 2019. PMID: 31400711 Review.

5

Discovery, molecular dynamic simulation and biological evaluation of structurally diverse cholinesterase inhibitors with new scaffold through shape-based pharmacophore virtual screening.

Yang H, Du C, Li Q, Chen T, Lu X, Li Q, Feng F, Chen Y, Liu W, Sun H. Yang H, et al. Among authors: chen t, chen y. Bioorg Chem. 2019 Nov;92:103294. doi: 10.1016/j.bioorg.2019.103294. Epub 2019 Sep 19. Bioorg Chem. 2019. PMID: 31557623

6

Design, synthesis, biological evaluation, and molecular modeling studies of quinoline-ferulic acid hybrids as cholinesterase inhibitors.

Mo J, Yang H, Chen T, Li Q, Lin H, Feng F, Liu W, Qu W, Guo Q, Chi H, Chen Y, Sun H. Mo J, et al. Among authors: chen t, chen y. Bioorg Chem. 2019 Dec;93:103310. doi: 10.1016/j.bioorg.2019.103310. Epub 2019 Sep 23. Bioorg Chem. 2019. PMID: 31586704

7

Design, synthesis, in vitro and in vivo evaluation of benzylpiperidine-linked 1,3-dimethylbenzimidazolinones as cholinesterase inhibitors against Alzheimer's disease.

Mo J, Chen T, Yang H, Guo Y, Li Q, Qiao Y, Lin H, Feng F, Liu W, Chen Y, Liu Z, Sun H. Mo J, et al. Among authors: chen t, chen y. J Enzyme Inhib Med Chem. 2020 Dec;35(1):330-343. doi: 10.1080/14756366.2019.1699553. J Enzyme Inhib Med Chem. 2020. PMID: 31856607 Free PMC article.

8

Design, Synthesis, and Evaluation of Acetylcholinesterase and Butyrylcholinesterase Dual-Target Inhibitors against Alzheimer's Diseases.

Guo Y, Yang H, Huang Z, Tian S, Li Q, Du C, Chen T, Liu Y, Sun H, Liu Z. Guo Y, et al. Among authors: chen t. Molecules. 2020 Jan 23;25(3):489. doi: 10.3390/molecules25030489. Molecules. 2020. PMID: 31979317 Free PMC article.

9

Discovery of potent glycogen synthase kinase 3/cholinesterase inhibitors with neuroprotection as potential therapeutic agent for Alzheimer's disease.

Jiang X, Wang Y, Liu C, Xing C, Wang Y, Lyu W, Wang S, Li Q, Chen T, Chen Y, Feng F, Liu W, Sun H. Jiang X, et al. Among authors: chen t, chen y. Bioorg Med Chem. 2021 Jan 15;30:115940. doi: 10.1016/j.bmc.2020.115940. Epub 2020 Dec 11. Bioorg Med Chem. 2021. PMID: 33340937

10

The Design and Optimization of Monomeric Multitarget Peptides for the Treatment of Multifactorial Diseases.

Chen T, Sun T, Bian Y, Pei Y, Feng F, Chi H, Li Y, Tang X, Sang S, Du C, Chen Y, Chen Y, Sun H. Chen T, et al. Among authors: chen y. J Med Chem. 2022 Mar 10;65(5):3685-3705. doi: 10.1021/acs.jmedchem.1c01456. Epub 2022 Feb 21. J Med Chem. 2022. PMID: 35188373

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