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Serotonin transporter inhibition and 5-HT2C receptor activation drive loss of cocaine-induced locomotor activation in DAT Val559 mice.
Stewart A, Davis GL, Gresch PJ, Katamish RM, Peart R, Rabil MJ, Gowrishankar R, Carroll FI, Hahn MK, Blakely RD. Stewart A, et al. Among authors: gowrishankar r. Neuropsychopharmacology. 2019 Apr;44(5):994-1006. doi: 10.1038/s41386-018-0301-8. Epub 2018 Dec 21. Neuropsychopharmacology. 2019. PMID: 30578419 Free PMC article.
The rare DAT coding variant Val559 perturbs DA neuron function, changes behavior, and alters in vivo responses to psychostimulants.
Mergy MA, Gowrishankar R, Gresch PJ, Gantz SC, Williams J, Davis GL, Wheeler CA, Stanwood GD, Hahn MK, Blakely RD. Mergy MA, et al. Among authors: gowrishankar r. Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):E4779-88. doi: 10.1073/pnas.1417294111. Epub 2014 Oct 20. Proc Natl Acad Sci U S A. 2014. PMID: 25331903 Free PMC article.
Behaviorally penetrant, anomalous dopamine efflux exposes sex and circuit dependent regulation of dopamine transporters.
Stewart A, Mayer FP, Gowrishankar R, Davis GL, Areal LB, Gresch PJ, Katamish RM, Peart R, Stilley SE, Spiess K, Rabil MJ, Diljohn FA, Wiggins AE, Vaughan RA, Hahn MK, Blakely RD. Stewart A, et al. Among authors: gowrishankar r. Mol Psychiatry. 2022 Dec;27(12):4869-4880. doi: 10.1038/s41380-022-01773-7. Epub 2022 Sep 18. Mol Psychiatry. 2022. PMID: 36117213
Antipsychotic drug-like effects of the selective M4 muscarinic acetylcholine receptor positive allosteric modulator VU0152100.
Byun NE, Grannan M, Bubser M, Barry RL, Thompson A, Rosanelli J, Gowrishankar R, Kelm ND, Damon S, Bridges TM, Melancon BJ, Tarr JC, Brogan JT, Avison MJ, Deutch AY, Wess J, Wood MR, Lindsley CW, Gore JC, Conn PJ, Jones CK. Byun NE, et al. Among authors: gowrishankar r. Neuropsychopharmacology. 2014 Jun;39(7):1578-93. doi: 10.1038/npp.2014.2. Epub 2014 Jan 20. Neuropsychopharmacology. 2014. PMID: 24442096 Free PMC article.
Ventral tegmental area GABAergic inhibition of cholinergic interneurons in the ventral nucleus accumbens shell promotes reward reinforcement.
Al-Hasani R, Gowrishankar R, Schmitz GP, Pedersen CE, Marcus DJ, Shirley SE, Hobbs TE, Elerding AJ, Renaud SJ, Jing M, Li Y, Alvarez VA, Lemos JC, Bruchas MR. Al-Hasani R, et al. Among authors: gowrishankar r. Nat Neurosci. 2021 Oct;24(10):1414-1428. doi: 10.1038/s41593-021-00898-2. Epub 2021 Aug 12. Nat Neurosci. 2021. PMID: 34385700 Free PMC article.
39 results