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Acid-Induced Downregulation of ASS1 Contributes to the Maintenance of Intracellular pH in Cancer.
Silberman A, Goldman O, Boukobza Assayag O, Jacob A, Rabinovich S, Adler L, Lee JS, Keshet R, Sarver A, Frug J, Stettner N, Galai S, Persi E, Halpern KB, Zaltsman-Amir Y, Pode-Shakked B, Eilam R, Anikster Y, Nagamani SCS, Ulitsky I, Ruppin E, Erez A. Silberman A, et al. Among authors: keshet r. Cancer Res. 2019 Feb 1;79(3):518-533. doi: 10.1158/0008-5472.CAN-18-1062. Epub 2018 Dec 20. Cancer Res. 2019. PMID: 30573518 Free PMC article.
Targeting purine synthesis in ASS1-expressing tumors enhances the response to immune checkpoint inhibitors.
Keshet R, Lee JS, Adler L, Iraqi M, Ariav Y, Lim LQJ, Lerner S, Rabinovich S, Oren R, Katzir R, Weiss Tishler H, Stettner N, Goldman O, Landesman H, Galai S, Kuperman Y, Kuznetsov Y, Brandis A, Mehlman T, Malitsky S, Itkin M, Koehler SE, Zhao Y, Talsania K, Shen TW, Peled N, Ulitsky I, Porgador A, Ruppin E, Erez A. Keshet R, et al. Nat Cancer. 2020 Sep;1(9):894-908. doi: 10.1038/s43018-020-0106-7. Epub 2020 Aug 31. Nat Cancer. 2020. PMID: 35121952
Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures.
Lee JS, Adler L, Karathia H, Carmel N, Rabinovich S, Auslander N, Keshet R, Stettner N, Silberman A, Agemy L, Helbling D, Eilam R, Sun Q, Brandis A, Malitsky S, Itkin M, Weiss H, Pinto S, Kalaora S, Levy R, Barnea E, Admon A, Dimmock D, Stern-Ginossar N, Scherz A, Nagamani SCS, Unda M, Wilson DM 3rd, Elhasid R, Carracedo A, Samuels Y, Hannenhalli S, Ruppin E, Erez A. Lee JS, et al. Among authors: keshet r. Cell. 2018 Sep 6;174(6):1559-1570.e22. doi: 10.1016/j.cell.2018.07.019. Epub 2018 Aug 9. Cell. 2018. PMID: 30100185 Free PMC article.
c-Abl forces YAP to switch sides.
Keshet R, Reuven N, Shaul Y. Keshet R, et al. Mol Cell Oncol. 2015 Jan 23;2(3):e995006. doi: 10.4161/23723556.2014.995006. eCollection 2015 Jul-Sep. Mol Cell Oncol. 2015. PMID: 27308475 Free PMC article.
c-Abl antagonizes the YAP oncogenic function.
Keshet R, Adler J, Ricardo Lax I, Shanzer M, Porat Z, Reuven N, Shaul Y. Keshet R, et al. Cell Death Differ. 2015 Jun;22(6):935-45. doi: 10.1038/cdd.2014.182. Epub 2014 Oct 31. Cell Death Differ. 2015. PMID: 25361080 Free PMC article.
Dual Regulatory Role of Polyamines in Adipogenesis.
Brenner S, Bercovich Z, Feiler Y, Keshet R, Kahana C. Brenner S, et al. Among authors: keshet r. J Biol Chem. 2015 Nov 6;290(45):27384-27392. doi: 10.1074/jbc.M115.686980. Epub 2015 Sep 22. J Biol Chem. 2015. PMID: 26396188 Free PMC article.
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