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Improvement of Aqueous Solubility of Lapatinib-Derived Analogues: Identification of a Quinolinimine Lead for Human African Trypanosomiasis Drug Development.
Bachovchin KA, Sharma A, Bag S, Klug DM, Schneider KM, Singh B, Jalani HB, Buskes MJ, Mehta N, Tanghe S, Momper JD, Sciotti RJ, Rodriguez A, Mensa-Wilmot K, Pollastri MP, Ferrins L. Bachovchin KA, et al. Among authors: tanghe s. J Med Chem. 2019 Jan 24;62(2):665-687. doi: 10.1021/acs.jmedchem.8b01365. Epub 2019 Jan 10. J Med Chem. 2019. PMID: 30565932 Free PMC article.
Corrigendum to "Optimization of physicochemical properties for 4-Anilinoquinazoline inhibitors of trypanosome proliferation" [Eur. J. Med. Chem. 141 (2017) 446-459].
Woodring JL, Bachovchin KA, Brady KG, Gallerstein MF, Erath J, Tanghe S, Leed SE, Rodriguez A, Mensa-Wilmot K, Sciotti RJ, Pollastri MP. Woodring JL, et al. Among authors: tanghe s. Eur J Med Chem. 2018 May 25;152:515. doi: 10.1016/j.ejmech.2018.05.002. Epub 2018 May 10. Eur J Med Chem. 2018. PMID: 29754075 No abstract available.
Anilinoquinoline based inhibitors of trypanosomatid proliferation.
Ferrins L, Sharma A, Thomas SM, Mehta N, Erath J, Tanghe S, Leed SE, Rodriguez A, Mensa-Wilmot K, Sciotti RJ, Gillingwater K, Pollastri MP. Ferrins L, et al. Among authors: tanghe s. PLoS Negl Trop Dis. 2018 Nov 26;12(11):e0006834. doi: 10.1371/journal.pntd.0006834. eCollection 2018 Nov. PLoS Negl Trop Dis. 2018. PMID: 30475800 Free PMC article.
Hit-to-Lead Optimization of a Novel Class of Potent, Broad-Spectrum Trypanosomacides.
Russell S, Rahmani R, Jones AJ, Newson HL, Neilde K, Cotillo I, Rahmani Khajouei M, Ferrins L, Qureishi S, Nguyen N, Martinez-Martinez MS, Weaver DF, Kaiser M, Riley J, Thomas J, De Rycker M, Read KD, Flematti GR, Ryan E, Tanghe S, Rodriguez A, Charman SA, Kessler A, Avery VM, Baell JB, Piggott MJ. Russell S, et al. Among authors: tanghe s. J Med Chem. 2016 Nov 10;59(21):9686-9720. doi: 10.1021/acs.jmedchem.6b00442. Epub 2016 Sep 19. J Med Chem. 2016. PMID: 27548560 Free article.
Structure-based approach to the identification of a novel group of selective glucosamine analogue inhibitors of Trypanosoma cruzi glucokinase.
D'Antonio EL, Deinema MS, Kearns SP, Frey TA, Tanghe S, Perry K, Roy TA, Gracz HS, Rodriguez A, D'Antonio J. D'Antonio EL, et al. Among authors: tanghe s. Mol Biochem Parasitol. 2015 Dec;204(2):64-76. doi: 10.1016/j.molbiopara.2015.12.004. Epub 2016 Jan 14. Mol Biochem Parasitol. 2015. PMID: 26778112 Free PMC article.
Small-molecule xenomycins inhibit all stages of the Plasmodium life cycle.
Erath J, Gallego-Delgado J, Xu W, Andriani G, Tanghe S, Gurova KV, Gudkov A, Purmal A, Rydkina E, Rodriguez A. Erath J, et al. Among authors: tanghe s. Antimicrob Agents Chemother. 2015 Mar;59(3):1427-34. doi: 10.1128/AAC.04704-14. Epub 2014 Dec 15. Antimicrob Agents Chemother. 2015. PMID: 25512429 Free PMC article.
Preclinical evaluation of strasseriolides A-D, potent antiplasmodial macrolides isolated from Strasseria geniculata CF-247,251.
Annang F, Pérez-Moreno G, Díaz C, González-Menéndez V, de Pedro Montejo N, Del Palacio JP, Sánchez P, Tanghe S, Rodriguez A, Pérez-Victoria I, Cantizani J, Ruiz-Pérez LM, Genilloud O, Reyes F, Vicente F, González-Pacanowska D. Annang F, et al. Among authors: tanghe s. Malar J. 2021 Dec 5;20(1):457. doi: 10.1186/s12936-021-03993-8. Malar J. 2021. PMID: 34865639 Free PMC article.
Targeting the Hexosamine Biosynthetic Pathway Prevents Plasmodium Developmental Cycle and Disease Pathology in Vertebrate Host.
Gomes PS, Tanghe S, Gallego-Delgado J, Conde L, Freire-de-Lima L, Lima AC, Freire-de-Lima CG, Lima Junior JDC, Moreira O, Totino P, Rodriguez A, Todeschini AR, Morrot A. Gomes PS, et al. Among authors: tanghe s. Front Microbiol. 2019 Feb 28;10:305. doi: 10.3389/fmicb.2019.00305. eCollection 2019. Front Microbiol. 2019. PMID: 30873136 Free PMC article.
31 results