Chibale K - Search Results

1

Structure-Activity Relationship Studies and Plasmodium Life Cycle Profiling Identifies Pan-Active N-Aryl-3-trifluoromethyl Pyrido[1,2- a]benzimidazoles Which Are Efficacious in an in Vivo Mouse Model of Malaria.

Mayoka G, Njoroge M, Okombo J, Gibhard L, Sanches-Vaz M, Fontinha D, Birkholtz LM, Reader J, van der Watt M, Coetzer TL, Lauterbach S, Churchyard A, Bezuidenhout B, Egan TJ, Yeates C, Wittlin S, Prudêncio M, Chibale K. Mayoka G, et al. Among authors: chibale k. J Med Chem. 2019 Jan 24;62(2):1022-1035. doi: 10.1021/acs.jmedchem.8b01769. Epub 2018 Dec 24. J Med Chem. 2019. PMID: 30562027

2

Synthesis of totarol amino alcohol derivatives and their antiplasmodial activity and cytotoxicity.

Clarkson C, Musonda CC, Chibale K, Campbell WE, Smith P. Clarkson C, et al. Among authors: chibale k. Bioorg Med Chem. 2003 Oct 1;11(20):4417-22. doi: 10.1016/s0968-0896(03)00491-7. Bioorg Med Chem. 2003. PMID: 13129578

3

Application of multi-component reactions to antimalarial drug discovery. Part 1: Parallel synthesis and antiplasmodial activity of new 4-aminoquinoline Ugi adducts.

Musonda CC, Taylor D, Lehman J, Gut J, Rosenthal PJ, Chibale K. Musonda CC, et al. Among authors: chibale k. Bioorg Med Chem Lett. 2004 Aug 2;14(15):3901-5. doi: 10.1016/j.bmcl.2004.05.063. Bioorg Med Chem Lett. 2004. PMID: 15225694

4

Design, synthesis and anti-plasmodial evaluation in vitro of new 4-aminoquinoline isatin derivatives.

Chiyanzu I, Clarkson C, Smith PJ, Lehman J, Gut J, Rosenthal PJ, Chibale K. Chiyanzu I, et al. Among authors: chibale k. Bioorg Med Chem. 2005 May 2;13(9):3249-61. doi: 10.1016/j.bmc.2005.02.037. Bioorg Med Chem. 2005. PMID: 15809160

5

Exploiting a basic chemosensitizing pharmacophore hypothesis. Part 1: synthesis and biological evaluation of novel arylbromide and bicyclic chemosensitizers against drug-resistant malaria parasites.

Chouteau F, Ramanitrahasimbola D, Rasoanaivo P, Chibale K. Chouteau F, et al. Among authors: chibale k. Bioorg Med Chem Lett. 2005 Jun 15;15(12):3024-8. doi: 10.1016/j.bmcl.2005.04.033. Bioorg Med Chem Lett. 2005. PMID: 15908208

6

Application of multicomponent reactions to antimalarial drug discovery. Part 2: New antiplasmodial and antitrypanosomal 4-aminoquinoline gamma- and delta-lactams via a 'catch and release' protocol.

Musonda CC, Gut J, Rosenthal PJ, Yardley V, Carvalho de Souza RC, Chibale K. Musonda CC, et al. Among authors: chibale k. Bioorg Med Chem. 2006 Aug 15;14(16):5605-15. doi: 10.1016/j.bmc.2006.04.035. Epub 2006 May 11. Bioorg Med Chem. 2006. PMID: 16690319

7

Synthesis of novel keto-ACE analogues as domain-selective angiotensin I-converting enzyme inhibitors.

Nchinda AT, Chibale K, Redelinghuys P, Sturrock ED. Nchinda AT, et al. Among authors: chibale k. Bioorg Med Chem Lett. 2006 Sep 1;16(17):4612-5. doi: 10.1016/j.bmcl.2006.06.003. Epub 2006 Jun 19. Bioorg Med Chem Lett. 2006. PMID: 16784850

8

Synthesis and biological evaluation of phenolic Mannich bases of benzaldehyde and (thio)semicarbazone derivatives against the cysteine protease falcipain-2 and a chloroquine resistant strain of Plasmodium falciparum.

Chipeleme A, Gut J, Rosenthal PJ, Chibale K. Chipeleme A, et al. Among authors: chibale k. Bioorg Med Chem. 2007 Jan 1;15(1):273-82. doi: 10.1016/j.bmc.2006.09.055. Epub 2006 Sep 29. Bioorg Med Chem. 2007. PMID: 17052908

9

Application of multicomponent reactions to antimalarial drug discovery. Part 3: discovery of aminoxazole 4-aminoquinolines with potent antiplasmodial activity in vitro.

Musonda CC, Little S, Yardley V, Chibale K. Musonda CC, et al. Among authors: chibale k. Bioorg Med Chem Lett. 2007 Sep 1;17(17):4733-6. doi: 10.1016/j.bmcl.2007.06.070. Epub 2007 Jun 27. Bioorg Med Chem Lett. 2007. PMID: 17644333

10

Metallocene-based antimalarials: an exploration into the influence of the ferrocenyl moiety on in vitro antimalarial activity in chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum.

Blackie MA, Beagley P, Croft SL, Kendrick H, Moss JR, Chibale K. Blackie MA, et al. Among authors: chibale k. Bioorg Med Chem. 2007 Oct 15;15(20):6510-6. doi: 10.1016/j.bmc.2007.07.012. Epub 2007 Aug 1. Bioorg Med Chem. 2007. PMID: 17693090

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