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Exploring the insulin secretory properties of the PGD2-GPR44/DP2 axis in vitro and in a randomized phase-1 trial of type 2 diabetes patients.
Skrtic S, Tyrberg B, Broberg M, Ericsson H, Schnecke V, Kjaer M, Hompesch M, Andersson EM, Ryberg E, Aivazidis A, Wennberg Huldt C, Löfgren L, Morrow L, Parkinson J, Rydén-Bergsten T, Watkins E, Sörhede Winzell M. Skrtic S, et al. Among authors: lofgren l. PLoS One. 2018 Dec 17;13(12):e0208998. doi: 10.1371/journal.pone.0208998. eCollection 2018. PLoS One. 2018. PMID: 30557325 Free PMC article. Clinical Trial.
Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats.
Bengtsson C, Blaho S, Saitton DB, Brickmann K, Broddefalk J, Davidsson O, Drmota T, Folmer R, Hallberg K, Hallén S, Hovland R, Isin E, Johannesson P, Kull B, Larsson LO, Löfgren L, Nilsson KE, Noeske T, Oakes N, Plowright AT, Schnecke V, Ståhlberg P, Sörme P, Wan H, Wellner E, Oster L. Bengtsson C, et al. Among authors: lofgren l. Bioorg Med Chem. 2011 May 15;19(10):3039-53. doi: 10.1016/j.bmc.2011.04.014. Epub 2011 Apr 13. Bioorg Med Chem. 2011. PMID: 21515056
Diacylglycerol acyltransferase 1 inhibition with AZD7687 alters lipid handling and hormone secretion in the gut with intolerable side effects: a randomized clinical trial.
Denison H, Nilsson C, Löfgren L, Himmelmann A, Mårtensson G, Knutsson M, Al-Shurbaji A, Tornqvist H, Eriksson JW. Denison H, et al. Among authors: lofgren l. Diabetes Obes Metab. 2014 Apr;16(4):334-43. doi: 10.1111/dom.12221. Epub 2013 Oct 31. Diabetes Obes Metab. 2014. PMID: 24118885 Clinical Trial.
Accurate measurement of endogenous adenosine in human blood.
Löfgren L, Pehrsson S, Hägglund G, Tjellström H, Nylander S. Löfgren L, et al. PLoS One. 2018 Oct 25;13(10):e0205707. doi: 10.1371/journal.pone.0205707. eCollection 2018. PLoS One. 2018. PMID: 30359421 Free PMC article.
Intestinal permeability is associated with visceral adiposity in healthy women.
Gummesson A, Carlsson LM, Storlien LH, Bäckhed F, Lundin P, Löfgren L, Stenlöf K, Lam YY, Fagerberg B, Carlsson B. Gummesson A, et al. Among authors: lofgren l. Obesity (Silver Spring). 2011 Nov;19(11):2280-2. doi: 10.1038/oby.2011.251. Epub 2011 Aug 18. Obesity (Silver Spring). 2011. PMID: 21852815 Free article.
138 results