Downs JA - Search Results

1

Repression of Transcription at DNA Breaks Requires Cohesin throughout Interphase and Prevents Genome Instability.

Meisenberg C, Pinder SI, Hopkins SR, Wooller SK, Benstead-Hume G, Pearl FMG, Jeggo PA, Downs JA. Meisenberg C, et al. Among authors: downs ja. Mol Cell. 2019 Jan 17;73(2):212-223.e7. doi: 10.1016/j.molcel.2018.11.001. Epub 2018 Dec 13. Mol Cell. 2019. PMID: 30554942 Free PMC article.

2

Requirement for PBAF in transcriptional repression and repair at DNA breaks in actively transcribed regions of chromatin.

Kakarougkas A, Ismail A, Chambers AL, Riballo E, Herbert AD, Künzel J, Löbrich M, Jeggo PA, Downs JA. Kakarougkas A, et al. Among authors: downs ja. Mol Cell. 2014 Sep 4;55(5):723-32. doi: 10.1016/j.molcel.2014.06.028. Epub 2014 Jul 24. Mol Cell. 2014. PMID: 25066234 Free PMC article.

3

Roles of chromatin remodellers in DNA double strand break repair.

Jeggo PA, Downs JA. Jeggo PA, et al. Among authors: downs ja. Exp Cell Res. 2014 Nov 15;329(1):69-77. doi: 10.1016/j.yexcr.2014.09.023. Epub 2014 Sep 30. Exp Cell Res. 2014. PMID: 25278484 Review.

4

The SWI/SNF chromatin remodelling complex: Its role in maintaining genome stability and preventing tumourigenesis.

Brownlee PM, Meisenberg C, Downs JA. Brownlee PM, et al. Among authors: downs ja. DNA Repair (Amst). 2015 Aug;32:127-133. doi: 10.1016/j.dnarep.2015.04.023. Epub 2015 May 1. DNA Repair (Amst). 2015. PMID: 25981841 Review.

5

The PBAF chromatin remodeling complex represses transcription and promotes rapid repair at DNA double-strand breaks.

Kakarougkas A, Downs JA, Jeggo PA. Kakarougkas A, et al. Among authors: downs ja. Mol Cell Oncol. 2015 Jan 23;2(1):e970072. doi: 10.4161/23723548.2014.970072. eCollection 2015 Jan-Mar. Mol Cell Oncol. 2015. PMID: 27308404 Free PMC article.

6

Chromatin modifiers and remodellers in DNA repair and signalling.

Jeggo PA, Downs JA, Gasser SM. Jeggo PA, et al. Among authors: downs ja. Philos Trans R Soc Lond B Biol Sci. 2017 Oct 5;372(1731):20160279. doi: 10.1098/rstb.2016.0279. Philos Trans R Soc Lond B Biol Sci. 2017. PMID: 28847816 Free PMC article. No abstract available.

7

Predicting synthetic lethal interactions using conserved patterns in protein interaction networks.

Benstead-Hume G, Chen X, Hopkins SR, Lane KA, Downs JA, Pearl FMG. Benstead-Hume G, et al. Among authors: downs ja. PLoS Comput Biol. 2019 Apr 17;15(4):e1006888. doi: 10.1371/journal.pcbi.1006888. eCollection 2019 Apr. PLoS Comput Biol. 2019. PMID: 30995217 Free PMC article.

8

Aneuploidy tolerance caused by BRG1 loss allows chromosome gains and recovery of fitness.

Schiavoni F, Zuazua-Villar P, Roumeliotis TI, Benstead-Hume G, Pardo M, Pearl FMG, Choudhary JS, Downs JA. Schiavoni F, et al. Among authors: downs ja. Nat Commun. 2022 Apr 1;13(1):1731. doi: 10.1038/s41467-022-29420-3. Nat Commun. 2022. PMID: 35365638 Free PMC article.

9

Defining Signatures of Arm-Wise Copy Number Change and Their Associated Drivers in Kidney Cancers.

Benstead-Hume G, Wooller SK, Downs JA, Pearl FMG. Benstead-Hume G, et al. Among authors: downs ja. Int J Mol Sci. 2019 Nov 16;20(22):5762. doi: 10.3390/ijms20225762. Int J Mol Sci. 2019. PMID: 31744086 Free PMC article.

10

The BAH domain of BAF180 is required for PCNA ubiquitination.

Niimi A, Hopkins SR, Downs JA, Masutani C. Niimi A, et al. Among authors: downs ja. Mutat Res. 2015 Sep;779:16-23. doi: 10.1016/j.mrfmmm.2015.06.006. Epub 2015 Jun 17. Mutat Res. 2015. PMID: 26117423

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