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Page 1
Combined Inhibition of DYRK1A, SMAD, and Trithorax Pathways Synergizes to Induce Robust Replication in Adult Human Beta Cells.
Wang P, Karakose E, Liu H, Swartz E, Ackeifi C, Zlatanic V, Wilson J, González BJ, Bender A, Takane KK, Ye L, Harb G, Pagliuca F, Homann D, Egli D, Argmann C, Scott DK, Garcia-Ocaña A, Stewart AF. Wang P, et al. Among authors: scott dk. Cell Metab. 2019 Mar 5;29(3):638-652.e5. doi: 10.1016/j.cmet.2018.12.005. Epub 2018 Dec 20. Cell Metab. 2019. PMID: 30581122 Free PMC article.
GLP-1 receptor agonists synergize with DYRK1A inhibitors to potentiate functional human β cell regeneration.
Ackeifi C, Wang P, Karakose E, Manning Fox JE, González BJ, Liu H, Wilson J, Swartz E, Berrouet C, Li Y, Kumar K, MacDonald PE, Sanchez R, Thorens B, DeVita R, Homann D, Egli D, Scott DK, Garcia-Ocaña A, Stewart AF. Ackeifi C, et al. Among authors: scott dk. Sci Transl Med. 2020 Feb 12;12(530):eaaw9996. doi: 10.1126/scitranslmed.aaw9996. Sci Transl Med. 2020. PMID: 32051230 Free PMC article.
Maladaptive positive feedback production of ChREBPβ underlies glucotoxic β-cell failure.
Katz LS, Brill G, Zhang P, Kumar A, Baumel-Alterzon S, Honig LB, Gómez-Banoy N, Karakose E, Tanase M, Doridot L, Alvarsson A, Davenport B, Wang P, Lambertini L, Stanley SA, Homann D, Stewart AF, Lo JC, Herman MA, Garcia-Ocaña A, Scott DK. Katz LS, et al. Among authors: scott dk. Nat Commun. 2022 Jul 30;13(1):4423. doi: 10.1038/s41467-022-32162-x. Nat Commun. 2022. PMID: 35908073 Free PMC article.
Author Correction: Maladaptive positive feedback production of ChREBPβ underlies glucotoxic β-cell failure.
Katz LS, Brill G, Zhang P, Kumar A, Baumel-Alterzon S, Honig LB, Gómez-Banoy N, Karakose E, Tanase M, Doridot L, Alvarsson A, Davenport B, Wang P, Lambertini L, Stanley SA, Homann D, Stewart AF, Lo JC, Herman MA, Garcia-Ocaña A, Scott DK. Katz LS, et al. Among authors: scott dk. Nat Commun. 2022 Sep 27;13(1):5681. doi: 10.1038/s41467-022-33243-7. Nat Commun. 2022. PMID: 36167859 Free PMC article. No abstract available.
Dendritic cells promote macrophage infiltration and comprise a substantial proportion of obesity-associated increases in CD11c+ cells in adipose tissue and liver.
Stefanovic-Racic M, Yang X, Turner MS, Mantell BS, Stolz DB, Sumpter TL, Sipula IJ, Dedousis N, Scott DK, Morel PA, Thomson AW, O'Doherty RM. Stefanovic-Racic M, et al. Among authors: scott dk. Diabetes. 2012 Sep;61(9):2330-9. doi: 10.2337/db11-1523. Epub 2012 Jul 30. Diabetes. 2012. PMID: 22851575 Free PMC article.
Replication confers β cell immaturity.
Puri S, Roy N, Russ HA, Leonhardt L, French EK, Roy R, Bengtsson H, Scott DK, Stewart AF, Hebrok M. Puri S, et al. Among authors: scott dk. Nat Commun. 2018 Feb 2;9(1):485. doi: 10.1038/s41467-018-02939-0. Nat Commun. 2018. PMID: 29396395 Free PMC article.
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