Morel SR - Search Results

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Development of posaconazole-based analogues as hedgehog signaling pathway inhibitors.

Teske KA, Dash RC, Morel SR, Chau LQ, Wechsler-Reya RJ, Hadden MK. Teske KA, et al. Among authors: morel sr. Eur J Med Chem. 2019 Feb 1;163:320-332. doi: 10.1016/j.ejmech.2018.11.056. Epub 2018 Nov 23. Eur J Med Chem. 2019. PMID: 30529635 Free PMC article.

Truncated Itraconazole Analogues Exhibiting Potent Anti-Hedgehog Activity and Improved Drug-like Properties.

Wen J, Chennamadhavuni D, Morel SR, Hadden MK. Wen J, et al. Among authors: morel sr. ACS Med Chem Lett. 2019 Aug 23;10(9):1290-1295. doi: 10.1021/acsmedchemlett.9b00188. eCollection 2019 Sep 12. ACS Med Chem Lett. 2019. PMID: 31531199 Free PMC article.

Structure-based virtual screening identifies an 8-hydroxyquinoline as a small molecule GLI1 inhibitor.

Dash RC, Wen J, Zaino AM, Morel SR, Chau LQ, Wechsler-Reya RJ, Hadden MK. Dash RC, et al. Among authors: morel sr. Mol Ther Oncolytics. 2021 Jan 16;20:265-276. doi: 10.1016/j.omto.2021.01.004. eCollection 2021 Mar 26. Mol Ther Oncolytics. 2021. PMID: 33614910 Free PMC article.

8-Hydroxyquinoline derivatives suppress GLI1-mediated transcription through multiple mechanisms.

Wen J, Charan Dash R, Zaino AM, Harrahill NJ, Calhoun JT, Dusek CO, Morel SR, Russolillo M, Kyle Hadden M. Wen J, et al. Among authors: morel sr. Bioorg Chem. 2023 Mar;132:106387. doi: 10.1016/j.bioorg.2023.106387. Epub 2023 Jan 21. Bioorg Chem. 2023. PMID: 36724660

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