Dane A - Search Results

1

Potential limits of AAV-based gene therapy with the use of new transgenes expressing factor IX fusion proteins.

Le Quellec S, Dane A, Enjolras N, McIntosh J, Rosales C, Negrier C, Nathwani A. Le Quellec S, et al. Among authors: dane a. Haemophilia. 2019 Jan;25(1):e11-e18. doi: 10.1111/hae.13651. Epub 2018 Dec 6. Haemophilia. 2019. PMID: 30520547

2

Recombinant Adeno-Associated Viral Vectors Expressing Human Coagulation FIX-E456H Variant in Hemophilia B Mice.

Le Quellec S, Dane AP, Barbon E, Bordet JC, Mingozzi F, Dargaud Y, Marais T, Biferi MG, Négrier C, Nathawani AC, Enjolras N. Le Quellec S, et al. Thromb Haemost. 2019 Dec;119(12):1956-1967. doi: 10.1055/s-0039-1697658. Epub 2019 Oct 28. Thromb Haemost. 2019. PMID: 31659733

3

Bioengineered AAV Capsids with Combined High Human Liver Transduction In Vivo and Unique Humoral Seroreactivity.

Paulk NK, Pekrun K, Zhu E, Nygaard S, Li B, Xu J, Chu K, Leborgne C, Dane AP, Haft A, Zhang Y, Zhang F, Morton C, Valentine MB, Davidoff AM, Nathwani AC, Mingozzi F, Grompe M, Alexander IE, Lisowski L, Kay MA. Paulk NK, et al. Among authors: dane ap. Mol Ther. 2018 Jan 3;26(1):289-303. doi: 10.1016/j.ymthe.2017.09.021. Epub 2017 Sep 25. Mol Ther. 2018. PMID: 29055620 Free PMC article.

4

Phase 1-2 Trial of AAVS3 Gene Therapy in Patients with Hemophilia B.

Chowdary P, Shapiro S, Makris M, Evans G, Boyce S, Talks K, Dolan G, Reiss U, Phillips M, Riddell A, Peralta MR, Quaye M, Patch DW, Tuddenham E, Dane A, Watissée M, Long A, Nathwani A. Chowdary P, et al. Among authors: dane a. N Engl J Med. 2022 Jul 21;387(3):237-247. doi: 10.1056/NEJMoa2119913. N Engl J Med. 2022. PMID: 35857660 Free article. Clinical Trial.

5

Transient suppression of hepatocellular replication in the mouse liver following transduction with recombinant adeno-associated virus.

Dane AP, Cunningham SC, Kok CY, Logan GJ, Alexander IE. Dane AP, et al. Gene Ther. 2015 Nov;22(11):917-22. doi: 10.1038/gt.2015.66. Epub 2015 Jul 30. Gene Ther. 2015. PMID: 26224361

6

Selection and evaluation of clinically relevant AAV variants in a xenograft liver model.

Lisowski L, Dane AP, Chu K, Zhang Y, Cunningham SC, Wilson EM, Nygaard S, Grompe M, Alexander IE, Kay MA. Lisowski L, et al. Among authors: dane ap. Nature. 2014 Feb 20;506(7488):382-6. doi: 10.1038/nature12875. Epub 2013 Dec 25. Nature. 2014. PMID: 24390344 Free PMC article.

7

Comparison of gene transfer to the murine liver following intraperitoneal and intraportal delivery of hepatotropic AAV pseudo-serotypes.

Dane AP, Wowro SJ, Cunningham SC, Alexander IE. Dane AP, et al. Gene Ther. 2013 Apr;20(4):460-4. doi: 10.1038/gt.2012.67. Epub 2012 Aug 16. Gene Ther. 2013. PMID: 22895507

8

Identification of liver-specific enhancer-promoter activity in the 3' untranslated region of the wild-type AAV2 genome.

Logan GJ, Dane AP, Hallwirth CV, Smyth CM, Wilkie EE, Amaya AK, Zhu E, Khandekar N, Ginn SL, Liao SHY, Cunningham SC, Sasaki N, Cabanes-Creus M, Tam PPL, Russell DW, Lisowski L, Alexander IE. Logan GJ, et al. Nat Genet. 2017 Aug;49(8):1267-1273. doi: 10.1038/ng.3893. Epub 2017 Jun 19. Nat Genet. 2017. PMID: 28628105

9

Gene delivery to the juvenile mouse liver using AAV2/8 vectors.

Cunningham SC, Dane AP, Spinoulas A, Logan GJ, Alexander IE. Cunningham SC, et al. Among authors: dane ap. Mol Ther. 2008 Jun;16(6):1081-8. doi: 10.1038/mt.2008.72. Epub 2008 Apr 15. Mol Ther. 2008. PMID: 18414478 Free article.

10

Sexually dimorphic patterns of episomal rAAV genome persistence in the adult mouse liver and correlation with hepatocellular proliferation.

Dane AP, Cunningham SC, Graf NS, Alexander IE. Dane AP, et al. Mol Ther. 2009 Sep;17(9):1548-54. doi: 10.1038/mt.2009.139. Epub 2009 Jun 30. Mol Ther. 2009. PMID: 19568224 Free PMC article.

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