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Properties of myelin altered peptide ligand cyclo(87-99)(Ala91,Ala96)MBP87-99 render it a promising drug lead for immunotherapy of multiple sclerosis.
Deraos G, Rodi M, Kalbacher H, Chatzantoni K, Karagiannis F, Synodinos L, Plotas P, Papalois A, Dimisianos N, Papathanasopoulos P, Gatos D, Tselios T, Apostolopoulos V, Mouzaki A, Matsoukas J. Deraos G, et al. Among authors: kalbacher h. Eur J Med Chem. 2015 Aug 28;101:13-23. doi: 10.1016/j.ejmech.2015.06.015. Epub 2015 Jun 17. Eur J Med Chem. 2015. PMID: 26112377
Design and synthesis of a novel potent myelin basic protein epitope 87-99 cyclic analogue: enhanced stability and biological properties of mimics render them a potentially new class of immunomodulators.
Matsoukas J, Apostolopoulos V, Kalbacher H, Papini AM, Tselios T, Chatzantoni K, Biagioli T, Lolli F, Deraos S, Papathanassopoulos P, Troganis A, Mantzourani E, Mavromoustakos T, Mouzaki A. Matsoukas J, et al. Among authors: kalbacher h. J Med Chem. 2005 Mar 10;48(5):1470-80. doi: 10.1021/jm040849g. J Med Chem. 2005. PMID: 15743189
Autophagy promotes MHC class II presentation of peptides from intracellular source proteins.
Dengjel J, Schoor O, Fischer R, Reich M, Kraus M, Müller M, Kreymborg K, Altenberend F, Brandenburg J, Kalbacher H, Brock R, Driessen C, Rammensee HG, Stevanovic S. Dengjel J, et al. Among authors: kalbacher h. Proc Natl Acad Sci U S A. 2005 May 31;102(22):7922-7. doi: 10.1073/pnas.0501190102. Epub 2005 May 13. Proc Natl Acad Sci U S A. 2005. PMID: 15894616 Free PMC article.
273 results