Zeta Inhibitory Peptide Disrupts Electrostatic Interactions That Maintain Atypical Protein Kinase C in Its Active Conformation on the Scaffold p62.
Tsai LC, Xie L, Dore K, Xie L, Del Rio JC, King CC, Martinez-Ariza G, Hulme C, Malinow R, Bourne PE, Newton AC.
Tsai LC, et al. Among authors: malinow r.
J Biol Chem. 2015 Sep 4;290(36):21845-56. doi: 10.1074/jbc.M115.676221. Epub 2015 Jul 17.
J Biol Chem. 2015.
PMID: 26187466
Free PMC article.
A myristoylated peptide based on the autoinhibitory pseudosubstrate fragment of the atypical PKCzeta, zeta inhibitory peptide (ZIP), has been extensively used to inhibit aPKC activity; however, we have previously shown that ZIP does not inhibit the catalytic activity of aPKC isoz …
A myristoylated peptide based on the autoinhibitory pseudosubstrate fragment of the atypical PKCzeta, zeta inhibitory peptide (ZIP), has bee …