Hyvönen M - Search Results

1

Balancing Specificity and Promiscuity in Enzyme Evolution: Multidimensional Activity Transitions in the Alkaline Phosphatase Superfamily.

van Loo B, Bayer CD, Fischer G, Jonas S, Valkov E, Mohamed MF, Vorobieva A, Dutruel C, Hyvönen M, Hollfelder F. van Loo B, et al. Among authors: hyvonen m. J Am Chem Soc. 2019 Jan 9;141(1):370-387. doi: 10.1021/jacs.8b10290. Epub 2018 Dec 20. J Am Chem Soc. 2019. PMID: 30497259

2

A new member of the alkaline phosphatase superfamily with a formylglycine nucleophile: structural and kinetic characterisation of a phosphonate monoester hydrolase/phosphodiesterase from Rhizobium leguminosarum.

Jonas S, van Loo B, Hyvönen M, Hollfelder F. Jonas S, et al. Among authors: hyvonen m. J Mol Biol. 2008 Dec 5;384(1):120-36. doi: 10.1016/j.jmb.2008.08.072. Epub 2008 Sep 4. J Mol Biol. 2008. PMID: 18793651

3

An efficient, multiply promiscuous hydrolase in the alkaline phosphatase superfamily.

van Loo B, Jonas S, Babtie AC, Benjdia A, Berteau O, Hyvönen M, Hollfelder F. van Loo B, et al. Among authors: hyvonen m. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):2740-5. doi: 10.1073/pnas.0903951107. Epub 2010 Jan 27. Proc Natl Acad Sci U S A. 2010. PMID: 20133613 Free PMC article.

4

Targeting protein-protein interactions and fragment-based drug discovery.

Valkov E, Sharpe T, Marsh M, Greive S, Hyvönen M. Valkov E, et al. Among authors: hyvonen m. Top Curr Chem. 2012;317:145-79. doi: 10.1007/128_2011_265. Top Curr Chem. 2012. PMID: 22006238 Review.

5

Alternative modulation of protein-protein interactions by small molecules.

Fischer G, Rossmann M, Hyvönen M. Fischer G, et al. Among authors: hyvonen m. Curr Opin Biotechnol. 2015 Dec;35:78-85. doi: 10.1016/j.copbio.2015.04.006. Epub 2015 May 15. Curr Opin Biotechnol. 2015. PMID: 25935873 Free PMC article. Review.

6

Ultrahigh-throughput discovery of promiscuous enzymes by picodroplet functional metagenomics.

Colin PY, Kintses B, Gielen F, Miton CM, Fischer G, Mohamed MF, Hyvönen M, Morgavi DP, Janssen DB, Hollfelder F. Colin PY, et al. Among authors: hyvonen m. Nat Commun. 2015 Dec 7;6:10008. doi: 10.1038/ncomms10008. Nat Commun. 2015. PMID: 26639611 Free PMC article.

7

Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site.

Kasbekar M, Fischer G, Mott BT, Yasgar A, Hyvönen M, Boshoff HI, Abell C, Barry CE 3rd, Thomas CJ. Kasbekar M, et al. Among authors: hyvonen m. Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7503-8. doi: 10.1073/pnas.1600630113. Epub 2016 Jun 20. Proc Natl Acad Sci U S A. 2016. PMID: 27325754 Free PMC article.

8

Structure and activation of pro-activin A.

Wang X, Fischer G, Hyvönen M. Wang X, et al. Among authors: hyvonen m. Nat Commun. 2016 Jul 4;7:12052. doi: 10.1038/ncomms12052. Nat Commun. 2016. PMID: 27373274 Free PMC article.

9

Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51.

Moschetti T, Sharpe T, Fischer G, Marsh ME, Ng HK, Morgan M, Scott DE, Blundell TL, R Venkitaraman A, Skidmore J, Abell C, Hyvönen M. Moschetti T, et al. Among authors: hyvonen m. J Mol Biol. 2016 Nov 20;428(23):4589-4607. doi: 10.1016/j.jmb.2016.10.009. Epub 2016 Oct 8. J Mol Biol. 2016. PMID: 27725183 Free PMC article.

10

Macrocyclized Extended Peptides: Inhibiting the Substrate-Recognition Domain of Tankyrase.

Xu W, Lau YH, Fischer G, Tan YS, Chattopadhyay A, de la Roche M, Hyvönen M, Verma C, Spring DR, Itzhaki LS. Xu W, et al. Among authors: hyvonen m. J Am Chem Soc. 2017 Feb 15;139(6):2245-2256. doi: 10.1021/jacs.6b10234. Epub 2017 Feb 7. J Am Chem Soc. 2017. PMID: 28084734 Free PMC article.

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