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Page 1
Nucleosome Patterns in Circulating Tumor DNA Reveal Transcriptional Regulation of Advanced Prostate Cancer Phenotypes.
De Sarkar N, Patton RD, Doebley AL, Hanratty B, Adil M, Kreitzman AJ, Sarthy JF, Ko M, Brahma S, Meers MP, Janssens DH, Ang LS, Coleman IM, Bose A, Dumpit RF, Lucas JM, Nunez TA, Nguyen HM, McClure HM, Pritchard CC, Schweizer MT, Morrissey C, Choudhury AD, Baca SC, Berchuck JE, Freedman ML, Ahmad K, Haffner MC, Montgomery RB, Corey E, Henikoff S, Nelson PS, Ha G. De Sarkar N, et al. Among authors: sarthy jf. Cancer Discov. 2023 Mar 1;13(3):632-653. doi: 10.1158/2159-8290.CD-22-0692. Cancer Discov. 2023. PMID: 36399432 Free PMC article.
Chromatin Profiling of CBFA2T3-GLIS2 AMLs Identifies Key Transcription Factor Dependencies and BRG1 Inhibition as a Novel Therapeutic Strategy.
Kaonis S, Smith JL, Katiyar N, Merrill M, Hyelkma T, Namciu S, Le Q, Babaeva E, Ishida T, Morris SM, Girard E, Furuyama S, Ries R, Bernstein I, Meshinchi S, Henikoff S, Meers M, Hadland B, Sarthy JF. Kaonis S, et al. Among authors: sarthy jf. bioRxiv [Preprint]. 2023 Sep 1:2023.08.30.555598. doi: 10.1101/2023.08.30.555598. bioRxiv. 2023. PMID: 37693371 Free PMC article. Preprint.
KMT2A oncoproteins induce epigenetic resistance to targeted therapies.
Janssens DH, Duran M, Otto DJ, Wu W, Xu Y, Kirkey D, Mullighan CG, Yi JS, Meshinchi S, Sarthy JF, Ahmad K, Henikoff S. Janssens DH, et al. Among authors: sarthy jf. bioRxiv [Preprint]. 2024 Aug 12:2023.12.29.573681. doi: 10.1101/2023.12.29.573681. bioRxiv. 2024. PMID: 38234854 Free PMC article. Preprint.
Optimal therapeutic targeting by HDAC inhibition in biopsy-derived treatment-naïve diffuse midline glioma models.
Vitanza NA, Biery MC, Myers C, Ferguson E, Zheng Y, Girard EJ, Przystal JM, Park G, Noll A, Pakiam F, Winter CA, Morris SM, Sarthy J, Cole BL, Leary SES, Crane C, Lieberman NAP, Mueller S, Nazarian J, Gottardo R, Brusniak MY, Mhyre AJ, Olson JM. Vitanza NA, et al. Among authors: sarthy j. Neuro Oncol. 2021 Mar 25;23(3):376-386. doi: 10.1093/neuonc/noaa249. Neuro Oncol. 2021. PMID: 33130903 Free PMC article.
dCas9 fusion to computer-designed PRC2 inhibitor reveals functional TATA box in distal promoter region.
Levy S, Somasundaram L, Raj IX, Ic-Mex D, Phal A, Schmidt S, Ng WI, Mar D, Decarreau J, Moss N, Alghadeer A, Honkanen H, Sarthy J, Vitanza A, Hawkins RD, Mathieu J, Wang Y, Baker D, Bomsztyk K, Ruohola-Baker H. Levy S, et al. Among authors: sarthy j. Cell Rep. 2022 Mar 1;38(9):110457. doi: 10.1016/j.celrep.2022.110457. Cell Rep. 2022. PMID: 35235780 Free PMC article.
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